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Titolo:
Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach
Autore:
Yokose, T; Doy, M; Kakiki, M; Horie, T; Matsuzaki, Y; Mukai, K;
Indirizzi:
Natl Canc Ctr, Res Inst E, Div Pathol, Kashiwa, Chiba 2778577, Japan Natl Canc Ctr Kashiwa Chiba Japan 2778577 , Kashiwa, Chiba 2778577, Japan Tsukuba Med Ctr, Div Pathol, Tsukuba, Ibaraki 3058588, Japan Tsukuba Med Ctr Tsukuba Ibaraki Japan 3058588 uba, Ibaraki 3058588, Japan Eisain& Co Ltd, Strateg Drug Metab Res Unit, Tsukuba, Ibaraki 3002635, Japa Eisai & Co Ltd Tsukuba Ibaraki Japan 3002635 ukuba, Ibaraki 3002635, Japa Univ Tsukuba, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 10, volume: 89, anno: 1998,
pagine: 1028 - 1032
SICI:
0910-5050(199810)89:10<1028:EOCP3I>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LIVER; DIETARY AFLATOXINS; ENZYMES; CDNA; LOCALIZATION; SEQUENCE; CANCER; CARCINOMAS; ANTIBODY; RAT;
Keywords:
human; stomach; cytochrome P450 3A4; intestinal metaplasia; reverse transcription polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yokose, T Natlibanc Ctr, Res Inst E, Div Pathol, 5-1 Kashiwanoha 6 Chome, Kashiwa, Ch Natl Canc Ctr 5-1 Kashiwanoha 6 Chome Kashiwa Chiba Japan 2778577
Citazione:
T. Yokose et al., "Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach", JPN J CANC, 89(10), 1998, pp. 1028-1032

Abstract

The expression of cytochrome P450 3A4 (CYP3A4) in the foveolar epithelium of the human stomach with intestinal metaplasia was studied using immunohistochemistry, western blotting and reverse transcription polymerase ch ain reaction (RT-PCR). CYP3A4 was immunohistochemically detected in the foveolarepithelium with intestinal metaplasia, but was not detected in foveolar epithelium without intestinal metaplasia, in the pyloric gland or in the fundic gland of the stomach, Western blotting and RT-PCR demonstrated that CYP3A4 protein and mRNA were expressed in the liver and pyloric gland mucosa with intestinal metaplasia, but not in the fundic gland mucose without intestinal metaplasia. Possible roles of CYP expression in the gastric mucose with intestinal metaplasia in human stomach carcinogenesis are briefly discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:36:14