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Titolo:
A third human CBL gene is on chromosome 19
Autore:
Ollendorff, V; Mattei, MG; Fournier, E; Adelaide, J; Lopez, M; Rosnet, O; Birnbaum, D;
Indirizzi:
INSERM, U119, F-13009 Marseille, France INSERM Marseille France F-13009INSERM, U119, F-13009 Marseille, France Inst J Paoli I Calmettes, F-13009 Marseille, France Inst J Paoli I Calmettes Marseille France F-13009 3009 Marseille, France INSERM, U406, F-13385 Marseille, France INSERM Marseille France F-13385INSERM, U406, F-13385 Marseille, France
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 13, anno: 1998,
pagine: 1159 - 1161
SICI:
1019-6439(199812)13:6<1159:ATHCGI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTOONCOGENE C-CBL; HYBRIDIZATION; EVOLUTION; REGULATOR; PROTEIN; REGIONS; KINASE;
Keywords:
CBL; chromosome 3; chromosome 11; chromosome 19; paralogy; tumor suppressor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Birnbaum, D INSERM, U119, 27 Bd Lei Roure, F-13009 Marseille, France INSERM 27 Bd Lei Roure Marseille France F-13009 eille, France
Citazione:
V. Ollendorff et al., "A third human CBL gene is on chromosome 19", INT J ONCOL, 13(6), 1998, pp. 1159-1161

Abstract

CBL genes encode cytoplasmic proteins involved in signal transduction downstream of a number of receptors including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. They seem to be transducers associatedwith negative regulation of signals, and, as such, may he potential tumor suppressors. Using a probe derived from an expressed sequence tag, we isolated a cosmid containing part of a new CBL gene, CBLc, related to the two characterized paralogous genes CBLa and CBLb. Using the cosmid in fluorescence in situ hybridization of human metaphase chromosomes, we localized the CBLc gene to band 13.2 of chromosome 19. We show that the 19q12.2-13.3 regionwhere CBLc is located shows paralogy with two other regions of the human genome, 3q22-q27 and 11q22-q24 where CBLb and CBLa are located, respectively. Genes from several other families are located in these regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 07:50:07