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Titolo:
A critical role for complement in maintenance of self-tolerance
Autore:
Prodeus, AP; Goerg, S; Shen, LM; Pozdnyakova, OO; Chu, L; Alicot, EM; Goodnow, CC; Carroll, MC;
Indirizzi:
Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 hol, Ctr Blood Res, Boston, MA 02115 USA AustralianTNatl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, AC Australian Natl Univ Canberra ACT Australia 2601 Genome Ctr, Canberra, AC
Titolo Testata:
IMMUNITY
fascicolo: 5, volume: 9, anno: 1998,
pagine: 721 - 731
SICI:
1074-7613(199811)9:5<721:ACRFCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; REACTIVE B-CELLS; T-DEPENDENT ANTIGEN; LYMPHOCYTE; MICE; KERATINOCYTES; EXPRESSION; THRESHOLDS; SELECTION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Carroll, MC Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 od Res, Boston, MA 02115 USA
Citazione:
A.P. Prodeus et al., "A critical role for complement in maintenance of self-tolerance", IMMUNITY, 9(5), 1998, pp. 721-731

Abstract

The role of complement in the maintenance of self-tolerance has been examined in two models: an immunoglobulin transgenic model of peripheral tolerance and a lupus-like murine model of CD95 (Fas) deficiency. We find that self-reactive B lymphocytes deficient in complement receptors CD21/CD35 or transferred into mice deficient in the complement protein C4 are not anergizedby soluble self-antigen. In the second model, deficiency in CD21/CD35 or C4 combined with CD95 deficiency results in high titers of anti-nuclear antibodies leading to severe lupus-like disease. These findings suggest a novelrole for the complement system in B cell tolerance and provide insight into the genetic association of complement deficiency with susceptibility to systemic lupus erythematosus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:40:30