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Titolo:
USE OF RHODOCOCCUS-EQUI VIRULENCE-ASSOCIATED PROTEIN FOR IMMUNIZATIONOF FOALS AGAINST RHODOCOCCUS-EQUI PNEUMONIA
Autore:
PRESCOTT JF; NICHOLSON VM; PATTERSON MC; MELEIRO MCZ; DEARAUJO AC; YAGER JA; HOLMES MA;
Indirizzi:
UNIV GUELPH,DEPT PATHOBIOL GUELPH ON N1G 2W1 CANADA INST ADOLFO LUTZ REGISTRO,SECRETARIA ESTADO SAUDE,GOVERNO ESTADO SAO PAULO SAO PAULO BRAZIL UNIV CAMBRIDGE,DEPT VET CLIN STUDIES CAMBRIDGE CB3 0ES ENGLAND
Titolo Testata:
American journal of veterinary research
fascicolo: 4, volume: 58, anno: 1997,
pagine: 356 - 359
SICI:
0002-9645(1997)58:4<356:UORVPF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
17-KILODALTON ANTIGENS; PULMONARY CLEARANCE; 15-KILODALTON; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Prescott et al., "USE OF RHODOCOCCUS-EQUI VIRULENCE-ASSOCIATED PROTEIN FOR IMMUNIZATIONOF FOALS AGAINST RHODOCOCCUS-EQUI PNEUMONIA", American journal of veterinary research, 58(4), 1997, pp. 356-359

Abstract

Objective-To evaluate use of the virulence-associated protein of Rhodococcus equi in immunizing foals against R equi pneumonia. Animals-Eight (experimental group) and 6 (controls) mares with their foals. Procedure-Virulence-associated protein extracted from R equi was used to prepare an acetone-precipitated, Triton X-extracted (APTX) antigen. After determination of the efficacy of passive immunization, in untreated foals or in foals given plasma from a horse vaccinated with APTX antigen or from a nonvaccinated horse, a field trial was done to evaluate the efficacy of vaccination of 8 mares, twice with APTX before parturition, and of their foals at ages 3 and 5 weeks; 6 mares and their foalsserved as unvaccinated controls. All 2-day-old foals were given plasma from local donor horses inoculated with a locally produced bacterin. Serum opsonizing activity produced by vaccination with APTX was determined. Passively immunized foals were challenge exposed with an aerosol of virulent R equi Foals of the field trial were exposed to enzooticinfection. Results-inoculation with APTX resulted in high IgG antibody titers with opsonizing activity. Passive immunization of foals with plasma from an immunized horse enhanced bacterial clearance from the lungs, compared with that in foals not given plasma or given plasma without APTX antibodies. Vaccination of mares and foals exposed to natural infection resulted in development of R equi pneumonia in 4 of 8 vaccinated foals, but in only 1 of 6 unvaccinated foals. Conclusions-Vaccination with APTX antigen led to high-titer, opsonizing antibody. Plasma from a vaccinated horse appeared to enhance clearance of R equi fromthe lungs of foals. Paradoxically, vaccination of mares and their foals with APTX antigen did not protect foals and may have enhanced R equi pneumonia in the foals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:17:54