Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blastogenic response of activated human umbilical cord blood T-lymphocytes
Autore:
DArena, G; Cascavilla, N; Carotenuto, M;
Indirizzi:
IRCCS,ondo, Sollievo Sofferenza Hosp, Div Hematol, I-71013 San Giovanni Rot IRCCS San Giovanni Rotondo Italy I-71013 matol, I-71013 San Giovanni Rot
Titolo Testata:
HAEMATOLOGICA
fascicolo: 11, volume: 83, anno: 1998,
pagine: 1048 - 1050
SICI:
0390-6078(199811)83:11<1048:BROAHU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; VERSUS-HOST DISEASE; TRANSPLANTATION; MOLECULE; LECTINS;
Keywords:
human umbilical cord blood; lymphocyte blastogenesis; flow cytometry;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: D'Arena, G IRCCS,ondo, Sollievo Sofferenza Hosp, Div Hematol, I-71013 San Giovanni Rot IRCCS San Giovanni Rotondo Italy I-71013 013 San Giovanni Rot
Citazione:
G. D'Arena et al., "Blastogenic response of activated human umbilical cord blood T-lymphocytes", HAEMATOLOG, 83(11), 1998, pp. 1048-1050

Abstract

Donor T-lymphocytes are thought to play a crucial role in both acute and chronic graft-versus-host disease (GVHD), pathological conditions that frequently complicate allogeneic bone marrow transplantation.(1) These diseases are described as occurring with a lower incidence and lesser severity when human umbilical cord blood (HUCB) cells, which have recently emerged as a potential source of hematopoietic progenitors, are used for transplantation.(2-6) This condition is probably related to the immaturity of neonatal HUCBT cells.(7,8) Lymphocyte blastogenic response to phytohemagglutinin (PHA),evaluated by means of flow cytometry, is a useful tool for testing the functional ability of T-cells to display an immune response against allo-antigens, reproducing In vitro the in vivo mechanism of activation. This study was designed to verify whether an impairment in HUCB T-cell ability to undergo an in vitro blastogenic response to mitogens could explain their reducedin vivo ability to induce GvHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:37:09