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Titolo:
Peripartal temporal course of endothelin 1, angiotensin II, and atrial natriuretic peptide in pre-eclampsia and normotensive pregnancy
Autore:
Zunker, P; Happe, S; Louwen, F; Evers, S; Ringelstein, EB;
Indirizzi:
Univ Hosp Kiel, Dept Neurol, D-24105 Kiel, Germany Univ Hosp Kiel Kiel Germany D-24105 , Dept Neurol, D-24105 Kiel, Germany
Titolo Testata:
FETAL DIAGNOSIS AND THERAPY
fascicolo: 5, volume: 13, anno: 1998,
pagine: 309 - 314
SICI:
1015-3837(199809/10)13:5<309:PTCOE1>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HYPERTENSION; CEREBRAL HEMODYNAMICS; SEVERE PREECLAMPSIA; PLASMA ENDOTHELIN; BLOOD-PRESSURE; ANP; ENCEPHALOPATHY; RENIN; MECHANISM; SYSTEM;
Keywords:
endothelin 1; angiotensin II; atrial natriuretic peptide; pre-eclampsia; high-risk pregnancy; hypertensive encephalopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Zunker, P Univ Hosp Kiel, Dept Neurol, Niemannsweg 147, D-24105 Kiel, Germany Univ Hosp Kiel Niemannsweg 147 Kiel Germany D-24105 el, Germany
Citazione:
P. Zunker et al., "Peripartal temporal course of endothelin 1, angiotensin II, and atrial natriuretic peptide in pre-eclampsia and normotensive pregnancy", FETAL DIAGN, 13(5), 1998, pp. 309-314

Abstract

Objective: To investigate the temporal peripartal course of plasma endothelin 1 (ET-I), angiotensin II (ANG II), and atrial natriuretic peptide (ANP)in patients with pre-eclampsia as compared to women with normotensive pregnancy. Methods: Levels of ET-1, ANG II, and ANP were measured by means of radio-immunoassay twice a week in 17 patients with pre-eclampsia and in 17 women with normotensive uncomplicated pregnancy during four different periods: (a) from admission to 1 week before delivery, (b) 1st week before delivery, (c) 1st week after delivery, and (d) 2nd week after delivery. Results: ET-1 levels were not statistically different between the two groups. ANG IIconcentrations were lower in the pre-eclampsia group than in the control group with statistical significance in period c (2.8 +/- 3.0 vs. 7.1 +/- 5.9pg/ml, mean +/- SD). ANP levels were higher in pre-eclamptic women than inthe control group, the difference being statistically significant in period a (54 +/- 46 vs. 11 +/- 16 pg/ml) and in period c (122 +/- 134 vs. 39 +/-22 pg/ml). Conclusions: There are considerable differences in ANP and ANG II concentrations during the peripartal period between patients with pre-eclampsia and normotensive pregnant women. Decreased ANG II and elevated ANP levels in the Ist week postpartum may reflect the clinical observation thatsome women deteriorate in this period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:23:39