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Titolo:
Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
Autore:
Alak, BM; Coskun, S; Friedman, CI; Kennard, EA; Kim, MH; Seifer, DB;
Indirizzi:
Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 t & Gynecol, Columbus, OH 43210 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 70, anno: 1998,
pagine: 1126 - 1130
SICI:
0015-0282(199812)70:6<1126:AASMMO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; INVITRO FERTILIZATION; OVARIAN FOLLICLES; MENSTRUAL-CYCLE; MESSENGER-RNAS; LOCALIZATION;
Keywords:
activin; inhibin; oocyte; granulosa cells; progesterone; estradiol; in vitro maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Alak, BM Ohio State Univ, Dept Obstet & Gynecol, 5th Floor Means Hall,1654Upham Dr, Ohio State Univ 5th Floor Means Hall,1654 Upham Dr Columbus OH USA 43210
Citazione:
B.M. Alak et al., "Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro", FERT STERIL, 70(6), 1998, pp. 1126-1130

Abstract

Objective To test the hypothesis that activin A promotes in vitro human oocyte meiotic maturation while inhibiting steroid secretion by nonluteinizedantral granulosa cells. Design: Prospective randomized controlled study. Setting: A university medical center. Patient(s): Nine women ranging in age from 31-44 years who were undergoingoophorectomy for nonovarian pathology. Intervention(s): Analysis of meiotic maturation of oocytes and steroid secretion by granulosa cells cultured in the presence or absence of activin A. Main Outcome Measure(s): Germinal vesicle breakdown (GVBD) and attainment of metaphase a (MII) in oocytes, and progesterone and E-2 secretion by granulosa cells. Result(s): Activin A significantly enhanced GVBD (91% vs. 65%) for controland maturation to Mn: (56% vs. 35% for control) of immature oocytes, Activin A significantly suppressed basal, and inhibin A-and FSH-stimulated progesterone and E-2 secretion by nonluteinized granulosa cells. Conclusion(s): Activin A is a promoter of oocyte maturation in vitro and amodulator of granulosa cell steroidogenesis in culture. (Fertil Steril(R) 1998;70:1126-30. (C) 1998 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:06:51