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Titolo:
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Autore:
Whitacre, KS; Seifer, DB; Friedman, CI; Coskun, S; Kennard, EA; Kim, MH; Alak, BM;
Indirizzi:
Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 t & Gynecol, Columbus, OH 43210 USA Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Anim Sci, Columbus, OH 43210 USA UnivlMed & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Obstet Gyneco Univ Med & Dent New Jersey New Brunswick NJ USA Sch, Dept Obstet Gyneco UnivUSAlif Irvine, Irvine Med Ctr, Dept Obstet & Gynecol, Orange, CA 92668Univ Calif Irvine Orange CA USA 92668 Obstet & Gynecol, Orange, CA 92668 King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr Riyadh Saudi Arabia 11211 i Arabia
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 70, anno: 1998,
pagine: 1015 - 1021
SICI:
0015-0282(199812)70:6<1015:EOOSPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FERTILIZATION IN-VITRO; DEVELOPMENTAL COMPETENCE; INVITRO FERTILIZATION; MATERNAL AGE; CRYOPRESERVATION; ANEUPLOIDY; PREGNANCY; WOMEN; STAGE;
Keywords:
human oocyte; oocyte maturation; germinal vesicle breakdown (GVBD); metaphase II (MII); menstrual cycle phase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Alak, BM Ohio State Univ, Dept Obstet & Gynecol, 5th Floor Means Hall,1654Upham Dr, Ohio State Univ 5th Floor Means Hall,1654 Upham Dr Columbus OH USA 43210
Citazione:
K.S. Whitacre et al., "Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes", FERT STERIL, 70(6), 1998, pp. 1015-1021

Abstract

Objective: To determine the efficiency of in vitro maturation, expressed by nuclear maturation, of oocytes aspirated during gynecologic surgeries or collected from excised ovaries. To assess the effect of patient age and cycle phase at collection on the oocyte's ability to mature in vitro. To examine the time course of oocyte maturation in vitro. Design: Nuclear maturation based on patient criteria compared. Setting: University-based IVF program and research center. Patient(s): Consented patients undergoing gynecologic surgeries or patients undergoing oophorectomy. Intervention(s): Oocytes were maintained in culture for 48 hours and evaluated for maturation. Main Outcome Measure(s): Nuclear maturation evaluated as germinal vesicle breakdown (GVBD) or progression to the metaphase II (MII) stage. Result(s): A significantly higher percentage of oocytes collected during the follicular phase of the menstrual cycle underwent GVBD than did oocytes collected during the luteal phase (60% versus 48%, respectively). The percentage of oocytes reaching the MII stage, from these two groups, was not different. No statistically significant differences in maturation were observed in oocytes from different ovarian sources or from patients >40 or <40 years of age. Conclusion(s): These data suggest that oocytes collected during the follicular phase are more likely to undergo GVBD than oocytes collected during the luteal phase. In this study, ovarian source, age, or cycle phase did not influence the final meiotic maturation of oocytes to metaphase II. (Fertil Steril(R) 1998;70: 1015-21. (C) 1998 by American Society for Reproductive Medicine.)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:41:25