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Titolo:
Selective inhibition of NF-kappa B activation by the flavonoid hepatoprotector silymarin in HepG2 - Evidence for different activating pathways
Autore:
Saliou, C; Rihn, B; Cillard, J; Okamoto, T; Packer, L;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA Univ Rennes 1, Fac Pharm, Biol Cellulaire Lab, F-35043 Rennes, France UnivRennes 1 Rennes France F-35043 llulaire Lab, F-35043 Rennes, France Instrance Rech & Secur, Lab Toxicol Expt & Ind, F-54500 Vandoeuvre Nancy, F Inst Natl Rech & Secur Vandoeuvre Nancy France F-54500 ndoeuvre Nancy, F Nagoya City Univ, Sch Med, Dept Mol Genet, Nagoya, Aichi 467, Japan NagoyaCity Univ Nagoya Aichi Japan 467 l Genet, Nagoya, Aichi 467, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 440, anno: 1998,
pagine: 8 - 12
SICI:
0014-5793(19981127)440:1-2<8:SIONBA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINE; TRANSCRIPTION FACTOR; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION; OKADAIC ACID; ALPHA; DEGRADATION; SILIBININ; PROTEINS; KINASE;
Keywords:
nuclear factor kappa-B; antioxidant; hepatocyte; flavonoid; silymarin; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Packer, L Univ Calif Berkeley, Dept Mol & Cell Biol, 251 Life Sci Addit, Berkeley, CA Univ Calif Berkeley 251 Life Sci Addit Berkeley CA USA 94720 CA
Citazione:
C. Saliou et al., "Selective inhibition of NF-kappa B activation by the flavonoid hepatoprotector silymarin in HepG2 - Evidence for different activating pathways", FEBS LETTER, 440(1-2), 1998, pp. 8-12

Abstract

The bioflavonoid silymarin is found to potently suppress both nuclear factor kappa-B (NF-kappa B)-DNA binding activity and its dependent gene expression induced by okadaic acid in the hepatoma cell line HepG2. Surprisingly, tumor necrosis factor-alpha-induced NF-kappa B activation was not affected by silymarin, thus demonstrating a pathway-dependent inhibition by silymarin. Many genes encoding the proteins of the hepatic acute phase response areunder the control of the transcription factor NF-kappa B, a key regulator in the inflammatory and immune reactions. Thus, the inhibitory effect of silymarin on NF-kappa B activation could be involved in its hepatoprotective property. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:54:02