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Titolo:
Changes in brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia, spinal cord, and gracile nuclei following cut or crush injuries
Autore:
Cho, HJ; Kim, JK; Park, HC; Kim, JK; Kim, DS; Ha, SO; Hong, HS;
Indirizzi:
Kyungpook Natl Univ, Sch Med, Dept Anat, Taegu 700422, South Korea Kyungpook Natl Univ Taegu South Korea 700422 , Taegu 700422, South Korea Kyungpook Natl Univ, Sch Med, Dept Neurol, Taegu 700422, South Korea Kyungpook Natl Univ Taegu South Korea 700422 , Taegu 700422, South Korea
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 154, anno: 1998,
pagine: 224 - 230
SICI:
0014-4886(199811)154:1<224:CIBNFI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; C-FOS EXPRESSION; SCIATIC-NERVE; MESSENGER-RNA; ELECTRICAL-STIMULATION; FACTOR RECEPTORS; PERIPHERAL INFLAMMATION; SCHWANN-CELLS; ADULT-RAT; NEURONS;
Keywords:
brain-derived neurotrophic factor; dorsal root ganglion; spinal cord; gracile nuclei; sciatic nerve injury; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Cho, HJ Kyungpookouthl Univ, Sch Med, Dept Anat, 2-101 Dongin Dong, Taegu 700422, S Kyungpook Natl Univ 2-101 Dongin Dong Taegu South Korea 700422 S
Citazione:
H.J. Cho et al., "Changes in brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia, spinal cord, and gracile nuclei following cut or crush injuries", EXP NEUROL, 154(1), 1998, pp. 224-230

Abstract

In the present study, we evaluated changes in brain-derived neurotrophic factor (BDNF) immunoreactivity in the rat lumbar (L) 5 dorsal root ganglion (DRG) and areas where afferents from the DRG terminate, the L5 spinal cord and gracile nuclei following unilateral sciatic nerve transection or crush. From 3 days to 4 weeks following cut or crush injury, the percentage of medium and large BDNF-immunoreactive neurons in the ipsilateral DRG increasedsignificantly compared with those on the contralateral side. Following cutinjury, there was no significant change in the percentage of small BDNF-immunoreactive neurons in the ipsilateral DRG;however, the intensity of immunoreactivity of these cells decreased. Following crush injury, however, boththe percentage and intensity of small BDNF-immunoreactive neurons in the ipsilateral DRG significantly increased. Following cut injury the expressionof BDNF-immunoreactive axonal fibers decreased markedly in the ipsilateralsuperficial laminae of the L5 spinal cord and increased significantly in the ipsilateral deeper laminae of the spinal cord and gracile nuclei. Crush injury induced a marked increase in the expression of BDNF-immunoreactive axonal fibers in the superficial laminae of the spinal cord as well as in the deeper laminae of the spinal cord and gracile nuclei. These differences in BDNF response in the DRG and spinal cord after cut or crush injuries may reflect differences in trophic support to the injured DRG neurons and altered neuronal. activity in the spinal cord and gracile nuclei following different types of peripheral nerve injury. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:35:24