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Titolo:
[I-125]EGF binding in basal ganglia of patients with Parkinson's disease and progressive supranuclear palsy and in MPTP-treated monkeys
Autore:
Villares, J; Faucheux, B; Herrero, MT; Obeso, JA; Duyckaerts, C; Hauw, JJ; Agid, Y; Hirsch, EC;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 289, F-75013 Paris, France Univ Murcia, Dept Anat, E-30071 Murcia, Spain Univ Murcia Murcia Spain E-30071 urcia, Dept Anat, E-30071 Murcia, Spain Univ Sao Paulo, CNPq, Dept Psychobiol, BR-05508 Sao Paulo, Brazil Univ SaoPaulo Sao Paulo Brazil BR-05508 iol, BR-05508 Sao Paulo, Brazil Quiron Clin, Dept Neurol & Funct Neurosurg, San Sebastian 20012, Spain Quiron Clin San Sebastian Spain 20012 rosurg, San Sebastian 20012, Spain Hop,La Pitie Salpetriere, INSERM, U360, Lab Neuropathol R Escourolle, Paris Hop La Pitie Salpetriere Paris France b Neuropathol R Escourolle, Paris
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 154, anno: 1998,
pagine: 146 - 156
SICI:
0014-4886(199811)154:1<146:[BIBGO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; MESENCEPHALIC DOPAMINERGIC-NEURONS; FACTOR RECEPTOR EXPRESSION; HUMAN NERVOUS-SYSTEM; RAT-BRAIN; FACTOR-ALPHA; NEUROTROPHIC FACTOR; SUBSTANTIA-NIGRA; MESSENGER-RNA; NIGROSTRIATAL SYSTEM;
Keywords:
Parkinson's disease; trophic factor; epidermal growth factor; dopaminergic neurons; receptor; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Hirsch, EC Hop La Pitie Salpetriere, INSERM, U289, 47 Blvd Hop, F-75013 Paris, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France F-75013 ance
Citazione:
J. Villares et al., "[I-125]EGF binding in basal ganglia of patients with Parkinson's disease and progressive supranuclear palsy and in MPTP-treated monkeys", EXP NEUROL, 154(1), 1998, pp. 146-156

Abstract

Since EGF is known to protect and stimulate the activity of dopaminergic neurons, an autoradiographic study of [I-125]EGF binding sites was performedin the striatum and pallidal complex in parkinsonian syndromes. The analysis was performed on posmortem brain tissues of three control subjects, three patients with Parkinson's disease, and three patients with progressive supranuclear palsy, another parkinsonian syndrome in which dopaminergic neurons also degenerate. Since all six patients had been treated with L-Dopa, wealso analyzed the effects of this drug in an animal model of Parkinson's disease. Quantitative analysis of [I-125] EGF binding was performed on the brains of three control monkeys, nine monkeys rendered parkinsonian by MPTP intoxication, three of which were treated with L-Dopa. An increased densityof [I-125]EGF binding was observed at anterior levels in the dorsal striatum, but not in the pallidum, of patients with Parkinson's disease and progressive supranuclear palsy. [I-125]EGF binding was unchanged in parkinsonianmonkeys whether or not they had been treated with L-Dopa. The data suggestan increased expression of EGFRs in the striatum in chronic parkinsonian syndromes but not in acute models of the disease. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:35:51