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Titolo:
Plasticity of tonotopic maps in auditory midbrain following partial cochlear damage in the developing chinchilla
Autore:
Harrison, RV; Ibrahim, D; Mount, RJ;
Indirizzi:
Hosp Sick Children, Dept Otolaryngol, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 4, volume: 123, anno: 1998,
pagine: 449 - 460
SICI:
0014-4819(199812)123:4<449:POTMIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOTOPIC ORGANIZATION; HEARING-LOSS; FREQUENCY REPRESENTATION; RESPONSE PROPERTIES; VISUAL-CORTEX; NERVE-SECTION; MOTOR MAPS; ADULT; NUCLEUS; SYSTEM;
Keywords:
cochleotopic map; cochlear hearing loss; inferior colliculus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, RV Hospnadak Children, Dept Otolaryngol, 555 Univ Ave, Toronto, ON M5G 1X8, Ca Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G 1X8 Ca
Citazione:
R.V. Harrison et al., "Plasticity of tonotopic maps in auditory midbrain following partial cochlear damage in the developing chinchilla", EXP BRAIN R, 123(4), 1998, pp. 449-460

Abstract

There is substantial reorganization of the midbrain (inferior colliculus) tonotopic map following neonatally induced partial cochlear lesions in the chinchilla. The most obvious feature of this remapping is a large "iso-frequency" region in the ventral sector of the central nucleus of inferior colliculus (ICC). Neurons in this region exhibit similar threshold and tuning properties, with a common characteristic frequency which corresponds to the high-frequency audiometric cutoff. This overrepresented frequency range also corresponds to the high-frequency border of the cochlear lesion. Alterations to the tonotopic map corresponding to lower frequencies, in more dorsalregions of ICC, depend on the extent and degree of the cochlear lesion. When there is minimal damage to apical (low-frequency) cochlear areas, the dorsal ICC has relatively normal frequency representations. With more extensive apical cochlear lesions there is a corresponding disruption of ICC tonotopic representation of the low frequencies. We conclude that the tonotopic map within the TCC can become (re)organized postnatally according to the abnormal pattern of neural activity from the auditory periphery. Similar reorganization can be expected to occur in human infants with a partial cochlear hearing loss from birth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:51:28