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Titolo:
Lung function and exercise capacity in thalassaemia major
Autore:
Cracowski, C; Wuyam, B; Klein, V; Levy, P;
Indirizzi:
Grenoble Hosp, Cardiopulm Lab, Grenoble, France Grenoble Hosp Grenoble France le Hosp, Cardiopulm Lab, Grenoble, France Grenoble Hosp, Dept Paediat, Grenoble, France Grenoble Hosp Grenoble France oble Hosp, Dept Paediat, Grenoble, France
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 12, anno: 1998,
pagine: 1130 - 1136
SICI:
0903-1936(199811)12:5<1130:LFAECI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-FUNCTION ABNORMALITIES; THALASSEMIA MAJOR; BETA-THALASSEMIA; DIFFUSING-CAPACITY; GAS-EXCHANGE; TRANSFUSION; CHILDREN; ANEMIA; SURVIVAL;
Keywords:
cardiac limitation; exercise testing; lung function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wuyam, B Hop A Michalon, Lab EFCR, BP 217 X, F-38043 Grenoble 09, France Hop A Michalon BP 217 X Grenoble France 09 3 Grenoble 09, France
Citazione:
C. Cracowski et al., "Lung function and exercise capacity in thalassaemia major", EUR RESP J, 12(5), 1998, pp. 1130-1136

Abstract

Lung function abnormalities in thalassaemia major are various and complex;however, patients still die from cardiac lesions. This study aimed to investigate pulmonary and cardiac involvement at an early stage in thalassaemicpatients and study their respective implications at rest and during exercise. Ten patients (five adults and five children) with thalassaemia major were investigated by echocardiography, lung function and exercise testing a few days after transfusion, All have had regular transfusions and chelation with deferoxamine and none had chronic pulmonary disease symptoms. Minor lung function abnormalities were found: two patients had moderate obstructive syndrome and two had a decreased carbon monoxide transfer factor. Hypoxaemia was never found at rest and no desaturation was observed at theend of exercise. Echocardiographic abnormalities were also moderate. Peak oxygen consumption (V(1)o(2),) was decreased in three adults and was lower in adults than children (means 27.7+/-4.6 and 41.1+/-4.8 mL.Kg(-1).min(-1) respectively),The V(1)o(2)/cardiac frequency slope was lower in adults thanchildren (0.25+/-0.06 versus 0.42+/-0.10 mL.kg(-1).min(-2)), whereas end-exercise breathing reserve was >40% maximal voluntary ventilation for all patients. In conclusion, none of the patients had ventilatory limitations but older patients had cardiac limitations assessed by the relationship between oxygen consumption and cardiac frequency. Exercise testing may detect cardiac impairment in thalassaemia major earlier than investigations at rest.

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Documento generato il 25/11/20 alle ore 18:14:06