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Titolo:
Cardiovascular effects of noradrenaline in hypovolemic haemorrhage: role of inducible nitric oxide synthase
Autore:
Tabrizchi, R;
Indirizzi:
Memnadav Newfoundland, Fac Med, Div Basic Med Sci, St Johns, NF A1B 3V6, Ca Mem Univ Newfoundland St Johns NF Canada A1B 3V6 St Johns, NF A1B 3V6, Ca
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 361, anno: 1998,
pagine: 227 - 234
SICI:
0014-2999(19981120)361:2-3<227:CEONIH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATORY FILLING PRESSURE; ARGININE METHYL-ESTER; ANESTHETIZED RATS; ENDOTOXIN-SHOCK; RELAXING FACTOR; CONSCIOUS RATS; VENOUS RETURN; ENDOTHELIUM; ARTERIAL; VASOPRESSIN;
Keywords:
cardiac output; hemorrhage; venous resistance; noradrenaline; nitric oxide (NO) synthase; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Tabrizchi, R Memnadav Newfoundland, Fac Med, Div Basic Med Sci, St Johns, NF A1B 3V6, Ca Mem Univ Newfoundland St Johns NF Canada A1B 3V6 A1B 3V6, Ca
Citazione:
R. Tabrizchi, "Cardiovascular effects of noradrenaline in hypovolemic haemorrhage: role of inducible nitric oxide synthase", EUR J PHARM, 361(2-3), 1998, pp. 227-234

Abstract

Hypovolemia has been associated with the induction of nitric oxide synthase which is believed to result in an over-production of nitric oxide. In thepresent study, we have examined the effects of noradrenaline following haemorrhage on cardiac output, blood pressure, mean circulatory filling pressure and vascular resistance in anaesthetized rats after pre-treatment with nitric oxide synthase inhibitor, L-N-6-(1-iminoethyl)lysine or dexamethasone. Hypovolemic haemorrhage resulted in induction of nitric oxide synthase, as measured in lungs, and both dexamethasone and L-N-6-(1-iminoethyl)lysine inhibited the activity of the inducible form of nitric oxide synthase. An infusion of noradrenaline significantly increased cardiac output, blood pressure and mean circulatory filling pressure in animals pre-treated with L-N-6-(1-inlinoethyl)lysine and dexamethasone when compared with saline pre-treatment. In addition, the administration of noradrenaline significantly reduced venous resistance in animals pre-treated with L-N-6-(1-iminoethyl)lysine when compared with saline pre-treatment. The results of this investigation indicated that the impact of noradrenaline on cardiac output, blood pressure and mean circulatory filling pressure was greater in hypovolemic rats treated with L-N-6-(1-iminoethyl)lysine or dexamethasone. In addition, we found that in the hypovolemic state, the greater increase in cardiac output during the infusion of noradrenaline after inhibition of nitric oxide synthase was predominantly due to reduced resistance to venous return. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:33:44