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Titolo:
Leptin and its receptors: Regulators of whole-body energy homeostasis
Autore:
Houseknecht, KL; Portocarrero, CP;
Indirizzi:
PurdueSAniv, Dept Anim Sci, Lab Endocrinol & Metab, W Lafayette, IN 47907 U Purdue Univ W Lafayette IN USA 47907 nol & Metab, W Lafayette, IN 47907 U
Titolo Testata:
DOMESTIC ANIMAL ENDOCRINOLOGY
fascicolo: 6, volume: 15, anno: 1998,
pagine: 457 - 475
SICI:
0739-7240(199811)15:6<457:LAIRRO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PROTEIN-ALPHA; OBESE GENE-PRODUCT; MESSENGER-RIBONUCLEIC-ACID; CEREBROSPINAL-FLUID LEPTIN; PANCREATIC BETA-CELLS; WHITE ADIPOSE-TISSUE; DIABETIC FATTY RATS; HUMAN OB GENE; NEUROPEPTIDE-Y; 3T3-L1 ADIPOCYTES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Houseknecht, KL Purdueyette, Dept Anim Sci, Lab Endocrinol & Metab, 1151 Lilly Hall, W Lafa Purdue Univ 1151 Lilly Hall W Lafayette IN USA 47907 Lafa
Citazione:
K.L. Houseknecht e C.P. Portocarrero, "Leptin and its receptors: Regulators of whole-body energy homeostasis", DOM ANIM EN, 15(6), 1998, pp. 457-475

Abstract

Leptin is the adipocyte-specific product of the ob gene. Expression of leptin in fully fed animals reflects adipocyte size and body-fat mass. Leptin signals the status of body energy stores to the brain, where signals emanate to regulate food intake and whole-body energy expenditure. The leptin gene was identified in the leptin-deficient, obese ob/ob mouse by positional cloning techniques. Recently, leptin has been cloned in domestic species including pigs, cattle, and chickens. The leptin receptor has at least five splice variants; the long form of the receptor is primarily expressed in the hypothalamus and is thought to be the predominant signaling isoform. Leptinreceptors are members of the cytokine family of receptors and signal via janus-activated kinases (JAK)/signal transducers and activators of transcription (STAT) and mitogen-activated protein kinase (MAPK) pathways. Mutationsin the leptin or leptin receptor genes results in morbid obesity, infertility, and insulin resistance in rodents and humans. Leptin regulates food intake and energy expenditure via central and peripheral mechanisms. Leptin receptors are expressed in: most tissues, and in vitro evidence suggests that leptin may have direct effects on some tissues such as adipose tissue, the adrenal cortex, and the pancreatic beta-cell. Leptin is thought to influence whole-body glucose homeostasis and insulin action. Studies are underwayto determine the role that leptin plays in the biology of domestic animals. (C) Elsevier Science Inc. 1998.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:42:23