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Titolo:
Differential recovery of sensorimotor function in GM1 ganglioside-treated vs. spontaneously recovered MPTP-treated cats: partial striatal dopaminergic reinnervation vs. neurochemical compensation
Autore:
Schneider, JS; Schroeder, JA; Rothblat, DS;
Indirizzi:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 Thomas Jefferson Univ Philadelphia PA USA 19107 l, Philadelphia, PA 19107
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 813, anno: 1998,
pagine: 82 - 87
SICI:
0006-8993(19981130)813:1<82:DROSFI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PARKINSONISM; VOLUME TRANSMISSION; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; NEOSTRIATUM; RAT;
Keywords:
striatum; dopamine; sensorimotor integration; MPTP; GM1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, JS Thomas,Jefferson Univ, Dept Pathol Anat & Cell Biol, 1020 Locust St,521 JAH Thomas Jefferson Univ 1020 Locust St,521 JAH Philadelphia PA USA 19107
Citazione:
J.S. Schneider et al., "Differential recovery of sensorimotor function in GM1 ganglioside-treated vs. spontaneously recovered MPTP-treated cats: partial striatal dopaminergic reinnervation vs. neurochemical compensation", BRAIN RES, 813(1), 1998, pp. 82-87

Abstract

Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to cats results in a parkinsonian syndrome characterized by rigidity, akinesia,bradykinesia, decreased response to external sensory stimuli and depletionof nigrostriatal dopamine. Cats spontaneously recover gross sensorimotor functions despite little recovery of the dopaminergic innervation of the striatum. in contrast, GM1 ganglioside administration accelerates gross behavioral recovery and causes an increased dopaminergic innervation of the striatum. This study examined whether these two recovery conditions are characterized by different degrees of functional recovery. Cats were trained to perform a sensorimotor reaching task prior to MPTP exposure and were then re-tested on the task 6 weeks later after spontaneously recovering gross motor functioning or after 6 weeks of GM1 treatment. Gross motor recovery was similar in both groups. However, the spontaneously recovered cats had significant difficulty in performing the task while GM1-treated cats performed normally. GM1-treated cats also had significant increases in striatal [H-3]mazindol binding compared to spontaneously recovered cats. These results suggest that while gross motor functions may improve to a similar extent with spontaneous and GM1-induced recovery from experimental parkinsonism, complex sensorimotor behavior recovers to different extents under the different recovery conditions. More complete behavioral recovery may depend upon at leasta partial recovery of striatal dopaminergic terminals rather than neurochemical compensation. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 11/07/20 alle ore 04:25:09