Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intra-septal injections of glucose and glibenclamide attenuate galanin-induced spontaneous alternation performance deficits in the rat
Autore:
Stefani, MR; Gold, PE;
Indirizzi:
Univ Virginia, Grad Program Neurosci, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 813, anno: 1998,
pagine: 50 - 56
SICI:
0006-8993(19981130)813:1<50:IIOGAG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE K+ CHANNELS; CENTRAL-NERVOUS-SYSTEM; HIPPOCAMPAL ACETYLCHOLINE OUTPUT; NONMATCHING-TO-SAMPLE; VENTRAL HIPPOCAMPUS; PHOSPHOINOSITIDE TURNOVER; SULFONYLUREA RECEPTOR; BINDING-SITES; MEDIAL SEPTUM; MORPHINE INJECTIONS;
Keywords:
glucose; memory; galanin; K-ATP; rat; spontaneous alternation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, PE Univ Virginia, Grad Program Neurosci, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 esville, VA 22903 USA
Citazione:
M.R. Stefani e P.E. Gold, "Intra-septal injections of glucose and glibenclamide attenuate galanin-induced spontaneous alternation performance deficits in the rat", BRAIN RES, 813(1), 1998, pp. 50-56

Abstract

Injection of the neuroactive peptide galanin into the rat hippocampus and medial septal area impairs spatial memory and cholinergic system activity. Conversely, injection of glucose into these same brain regions enhances spatial memory and cholinergic system activity. Glucose and galanin may both modulate neuronal activity via opposing actions at ATP-sensitive K+ (K-ATP) channels. The experiments described in this report tested the ability of glucose and the direct K-ATP channel blocker glibenclamide to attenuate galanin-induced impairments in spontaneous alternation performance in the rat. Intra-septal injection of galanin (2.5 mu g), 30 min prior to plus-maze spontaneous alternation performance, significantly decreased alternation scorescompared to those of rats receiving injections of vehicle solution. Co-injection of glucose (20 nmol) or the K-ATP channel blocker glibenclamide (5 nmol) attenuated the galanin-induced performance deficits. Glibenclamide produced an inverted-U dose-response curve in its interaction with galanin, with doses of 0.5 and 10 nmol having no effect on galanin-induced spontaneousalternation deficits. Drug treatments did not alter motor activity, as measured by overall number of arm entries during spontaneous alternation testing, relative to vehicle injected controls. These findings support the hypothesis that, in the septal region, galanin and glucose act via K-ATP channels to modulate neural function and behavior. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:08:31