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Titolo:
Effects of single oral administrations of haloperidol and d-amphetamine onprepulse inhibition of the acoustic startle reflex in healthy male volunteers
Autore:
Kumari, V; Mulligan, OF; Cotter, PA; Poon, L; Toone, BK; Checkley, SA; Gray, JA;
Indirizzi:
UnivLondonn, Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol,Univ London London England SE5 8AF hol Med, Sect Cognit Psychopharmacol, Univ London, Dept Psychol, London, England Univ London London EnglandUniv London, Dept Psychol, London, England Univ London, Dept Psychiat, London, England Univ London London EnglandUniv London, Dept Psychiat, London, England
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 7, volume: 9, anno: 1998,
pagine: 567 - 576
SICI:
0955-8810(199811)9:7<567:EOSOAO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODEL; SCHIZOPHRENIC-PATIENTS; LATENT INHIBITION; DOPAMINE; HABITUATION; STIMULATION; DEFICITS; NICOTINE; RATS; ANTAGONISTS;
Keywords:
d-amphetamine; haloperidol; prepulse inhibition (PPI); habituation; acoustic startle reflex; dopamine; schizophrenia; smoking; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kumari, V UnivDeondon, Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, Univ London De Crespigny Pk London England SE5 8AF hopharmacol,
Citazione:
V. Kumari et al., "Effects of single oral administrations of haloperidol and d-amphetamine onprepulse inhibition of the acoustic startle reflex in healthy male volunteers", BEHAV PHARM, 9(7), 1998, pp. 567-576

Abstract

The effects of acute administration of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers on habituation and prepulse inhibition (PPI) of the acoustic startle reflex in two experiments. In Experiment 1, 40 male non smoker volunteers were tested for habituation and PPI (defined as percentage reduction of the pulse-alone amplitude; prepulses 9 dB above background) before and after double-blind administration of either 2 mg haloperidol or placebo. No influence of haloperidol was observed on either habituation or PPI of the startle reflex in this experiment. In Experiment 2, 60 male volunteers underwent startle testing before and after double-blind administration of a single oral dose of 5 mg haloperidol, 5 mg d-amphetamine or placebo. Habituation and PPI (prepulses 15 dB above background) for the placebo group did not differ significantly from that observed for the d-amphetamine or for the haloperidol group. However, in a subgroup of smoking subjects, both d-amphetamine and haloperidol reduced PPI as compared to that observed prior to drug administration. The implications of these findings in relation to animal pharmacological studies and observed sensorimotor gating deficits in schizophrenia are discussed. Behav Pharmacol 1998; 9:567-576 (C) 1998 Lippincott Williams & Wilkins.

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Documento generato il 20/01/20 alle ore 22:09:22