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Titolo:
Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease
Autore:
Engelen, MPKJ; Schols, AMWJ; Heidendal, GAK; Wouters, EFM;
Indirizzi:
Univ Hosp Maastricht, Dept Pulm, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Nucl Med, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 68, anno: 1998,
pagine: 1298 - 1303
SICI:
0002-9165(199812)68:6<1298:DXAITC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOELECTRICAL-IMPEDANCE; NUTRITIONAL DEPLETION; PHOTON-ABSORPTIOMETRY; WATER; MASS; FAT; HEMODIALYSIS; MODELS; COPD; DEXA;
Keywords:
dual-energy X-ray absorptiometry; deuterium dilution; fat-free mass; bone mineral density; chronic obstructive pulmonary disease; COPD; adults;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Engelen, MPKJ Univdsosp Maastricht, Dept Pulm, POB 5800, NL-6202 AZ Maastricht, Netherlan Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M.P.K.J. Engelen et al., "Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease", AM J CLIN N, 68(6), 1998, pp. 1298-1303

Abstract

Background: Depletion of fat-foe mass (FFM) occurs in a considerable number of patients with chronic obstructive pulmonary disease (COPD). Objective: The goal of the study was to determine whether dual-energy X-ray absorptiometry (DXA) is an applicable method in the clinical evaluation of body composition in COPD. Design: In a cross-sectional study in 79 COPD patients participating in a pulmonary inpatient program and in 23 healthy volunteers, DXA was compared with deuterium dilution (Deu) in the estimation of FFM. Bone mineral density (BMD), a DXA measurement, was also compared between the 2 groups. Results: FFMDXA was highly related to FFMDeu in men (R-2 = 0.93, P < 0.001) and women (R-2 = 0.91, P < 0.001). On average, DXA resulted in higher FFMvalues than did Deu in COPD patients (3.4 kg; P < 0.001) and in healthy volunteers (2.1 kg; P < 0.001). Furthermore, the intramethod difference in FFM was higher in men than in women in the COPD group (P < 0.05) and in healthy volunteers (P < 0.001). BMD was lower in the COPD group than in the healthy, age-matched volunteers (P < 0.001). In 56% of the COPD patients, therewere indications of bone mineral loss, defined as a BMD ii SD of a matchedreference population provided by the software. BMD was < 2 SDs in 36% of the COPD patients. Conclusions: DXA appears to be a suitable alternative method to Deu for assessing body composition and is also of value in identifying bone mineral. loss in COPD patients, and is therefore applicable in the clinical evaluation of these patients.

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Documento generato il 08/08/20 alle ore 08:55:28