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Titolo:
Analysis of inhibitory effects of Scutellariae Radix and baicalein on prostaglandin E-2 production in rat C6 glioma cells
Autore:
Nakahata, N; Kutsuwa, M; Kyo, R; Kubo, M; Hayashi, K; Ohizumi, Y;
Indirizzi:
Tohoku Univ, Fac Pharmaceut Sci, Dept Pharmaceut Mol Biol, Aoba Ku, Sendai, Tohoku Univ Sendai Miyagi Japan 9808578 maceut Mol Biol, Aoba Ku, Sendai,
Titolo Testata:
AMERICAN JOURNAL OF CHINESE MEDICINE
fascicolo: 3-4, volume: 26, anno: 1998,
pagine: 311 - 324
SICI:
0192-415X(1998)26:3-4<311:AOIEOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; ARACHIDONIC-ACID; MAP KINASE; PHOSPHOINOSITIDE HYDROLYSIS; CONTRACTILE RESPONSES; PLATELET LIPOXYGENASE; CULTURED ASTROCYTES; RABBIT ASTROCYTES; GENERATION; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nakahata, N Tohoku Univ, Fac Pharmaceut Sci, Dept Pharmaceut Mol Biol, Aoba Ku, Sendai, Tohoku Univ Sendai Miyagi Japan 9808578 iol, Aoba Ku, Sendai,
Citazione:
N. Nakahata et al., "Analysis of inhibitory effects of Scutellariae Radix and baicalein on prostaglandin E-2 production in rat C6 glioma cells", AM J CHIN M, 26(3-4), 1998, pp. 311-324

Abstract

Inhibitory mechanism of the water extract of Scutelliariae Radix an prostaglandin E-2 (PGE(2)) release was examined in C6 rat glioma cells. Scutellariae Radix reduced a Ca2+ ionophore A23187-induced PGE(2) release by inhibition of arachidonic acid (AA) liberation. Sho-saiko-to and San'o-shashin-to,which contain Scutellariae Radix, also inhibited PGE(2) release. A23187 caused phosphorylation of mitogen-activated protein kinase (MAPK), resulting in activation of cytosolic phospholipase A(2) (cPLA(2)). Scutellariae Radixand baicalein inhibited the phosphorylation of MAPK. Baicalein, but not baicalin, inhibited A23187-induced PGE(2) release. These results suggest thatbaicalein in Scutellariae Radix reduces AA liberation through the inhibition of the MAPK-cPLA(2) pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:17:08