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Titolo:
Silicon reduces aluminum accumulation in rats: Relevance to the aluminum hypothesis of Alzheimer disease
Autore:
Belles, M; Sanchez, DJ; Gomez, M; Corbiella, J; Domingo, JL;
Indirizzi:
Univainvira & Virgili, Lab Toxicol & Environm Hlth, Sch Med, Reus 43201, Sp Univ Rovira & Virgili Reus Spain 43201 onm Hlth, Sch Med, Reus 43201, Sp Univ Barcelona, Sch Med, Toxicol Unit, Barcelona, Spain Univ Barcelona Barcelona Spain Sch Med, Toxicol Unit, Barcelona, Spain
Titolo Testata:
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
fascicolo: 2, volume: 12, anno: 1998,
pagine: 83 - 87
SICI:
0893-0341(199806)12:2<83:SRAAIR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRINKING-WATER; GASTROINTESTINAL ABSORPTION; ACUTE TOXICITY; ALUMINOSILICATES; SOLUBILIZATION; CHEMISTRY; MECHANISM; SILICATES; ACID; RISK;
Keywords:
aluminum; silicon; oral exposure; rats; tissue retention; urinary excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Domingo, JL Univ,Rovira & Virgili, Lab Toxicol & Environm Hlth, Sch Med, San Lorenzo 21 Univ Rovira & Virgili San Lorenzo 21 Reus Spain 43201 enzo 21
Citazione:
M. Belles et al., "Silicon reduces aluminum accumulation in rats: Relevance to the aluminum hypothesis of Alzheimer disease", ALZ DIS A D, 12(2), 1998, pp. 83-87

Abstract

In recent years, a possible relation between the aluminum and silicon levels in drinking water and the risk of Alzheimer disease (AD) has been established. It has been suggested that silicon may have a protective effect in limiting oral aluminum absorption. The present study was undertaken to examine the influence of supplementing silicon in the diet to prevent tissue aluminum retention in rats exposed to oral aluminum. Three groups of adult male rats were given by gavage 450 mg/kg/day of aluminum nitrate nonahydrate 5days a week for 5 weeks. Concurrently, animals received silicon in the drinking water at 0 (positive control), 59, and 118 mg Si/L. A fourth group (-Al, -Si) was designated as a negative control group. At the end of the period of aluminum and silicon administration, urines were collected for 4 consecutive days, and the urinary aluminum levels were determined. The aluminumconcentrations in the brain (various regions), liver, bone, spleen, and kidney were also measured. For all tissues, aluminum levels were significantly lower in the groups exposed to 59 and 118 mg Sin than in the positive control group; significant reductions in the urinary aluminum levels of the same groups were also found. The current results corroborate that silicon effectively prevents gastrointestinal aluminum absorption, which may be of concern in protecting against the neurotoxic effects of aluminum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:54:39