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Titolo:
ADDITIVE HYPOCHOLESTEROLEMIC EFFECT OF PSYLLIUM AND CHOLESTYRAMINE INTHE HAMSTER - INFLUENCE ON FECAL STEROL AND BILE-ACID PROFILES
Autore:
DAGGY BP; OCONNELL NC; JERDACK GR; STINSON BA; SETCHELL KDR;
Indirizzi:
CHILDRENS HOSP,MED CTR,CLIN MASS SPECTROMETRY CTR,3333 BURNET AVE CINCINNATI OH 45229 CHILDRENS HOSP,MED CTR,CLIN MASS SPECTROMETRY CTR CINCINNATI OH 45229 PROCTER & GAMBLE CO CINCINNATI OH 45040
Titolo Testata:
Journal of lipid research
fascicolo: 3, volume: 38, anno: 1997,
pagine: 491 - 502
SICI:
0022-2275(1997)38:3<491:AHEOPA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; CHOLESTEROL-LOWERING ACTION; LIPOPROTEIN RECEPTOR ACTIVITY; DIETARY FIBER; URSODEOXYCHOLIC ACID; MODERATE HYPERCHOLESTEROLEMIA; LIQUID-CHROMATOGRAPHY; PLASMA-LIPOPROTEINS; METABOLIC PROFILES; LDL-CHOLESTEROL;
Keywords:
CHOLESTEROL; FECES; MASS SPECTROMETRY; DIETARY FIBER; THERAPEUTIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
B.P. Daggy et al., "ADDITIVE HYPOCHOLESTEROLEMIC EFFECT OF PSYLLIUM AND CHOLESTYRAMINE INTHE HAMSTER - INFLUENCE ON FECAL STEROL AND BILE-ACID PROFILES", Journal of lipid research, 38(3), 1997, pp. 491-502

Abstract

Recent findings suggest that the effects of cholestyramine and psyllium in combination could be additive for cholesterol-lowering. We therefore examined the effect of both agents, alone and in combination, on lipoprotein cholesterol and neutral and acidic steroid excretion in the hamster. Animals (n = 8/group) were fed for 21 days, either a basal chow diet supplemented with 10% palm oil and 0.2% cholesterol, or one of four treatments consisting of the basal diet plus: 5.5% cellulose; 5% psyllium with 0.5% cellulose; 0.5% cholestyramine with 5% cellulose; or 5% psyllium with 0.5% cholestyramine. Psyllium and cholestyramineboth had significant hypocholesterolemic effects, but in combination produced additive reductions in lipoprotein and hepatic cholesterol. Psyllium, cholestyramine, and the combination increased total bile acidexcretion by 26%, 57%, and 79%, respectively. Psyllium affected only unconjugated bile acid excretion while cholestyramine also increased the excretion of conjugated and primary bile acids. Neither agent, nor the combination, affected fecal neutral sterol excretion. We conclude that, while both agents lower cholesterol by a mechanism of increased bile acid excretion, these studies indicate that psyllium does not bind bile acids in vivo and lend further support for the concomitant use of these agents for cholesterol-lowering.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:19:51