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Titolo:
ABSENCE OF NITRIC-OXIDE SYNTHASE-I DESPITE THE PRESENCE OF THE DYSTROPHIN COMPLEX IN HUMAN STRIATED-MUSCLE
Autore:
GROZDANOVIC Z; CHRISTOVA T; GOSZTONYI G; MELLEROWICZ H; BLOTTNER D; GOSSRAU R;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT ANAT D-14195 BERLIN GERMANY MED UNIV SOFIA,DEPT ANAT & HISTOL BG-1431 SOFIA BULGARIA FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT NEUROPATHOL D-12200 BERLIN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT ORTHOPED D-14195 BERLIN GERMANY
Titolo Testata:
Histochemical Journal
fascicolo: 2, volume: 29, anno: 1997,
pagine: 97 - 104
SICI:
0018-2214(1997)29:2<97:AONSDT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADPH-DIAPHORASE HISTOCHEMISTRY; SKELETAL-MUSCLE; SARCOLEMMA; NOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Z. Grozdanovic et al., "ABSENCE OF NITRIC-OXIDE SYNTHASE-I DESPITE THE PRESENCE OF THE DYSTROPHIN COMPLEX IN HUMAN STRIATED-MUSCLE", Histochemical Journal, 29(2), 1997, pp. 97-104

Abstract

Recently, it has been shown that in human striated muscle the signalling enzyme, brain-type nitric oxide synthase I (NOS I), is associated with the sarcolemma and complexes with dystrophin and/or members of the dystrophin complex. In order to find out whether there exists a regular association between NOS I and the complex, muscle biopsies from patients with various muscle disorders were analysed by enzyme histochemistry and immunohistochemistry. In patients suffering from Duchenne muscular dystrophy, and to a lesser extent in those with Becker-type dystrophy, NOS I and dystrophin complex components were absent or drastically reduced in the sarcolemma region. In other dystrophies, as well as in metabolic and inflammatory myopathies, NOS I and dystrophin complex constituents were expressed normally, while in the case of neurogenic diseases leading to denervation atrophy and especially congenital idiopathic clubfoot, the immunohistochemical patterns of the distribution of the dystrophin complex constituents were normal, but NOS I activity and protein were deficient or dramatically diminished. The resultscan be interpreted as indicating that, in general, NOS I targeting tothe sarcolemma is dependent on particular members of the dystrophin Complex, such as alpha-1 syntrophin, yet the expression and/or positioning of NOS I may be under the control of further factors, probably of neurogenic origin.-NOS I-associated diaphorase may thus be a useful complementary tool in the diagnosis of muscle disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:09:29