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Titolo:
THE HUMAN GASTRIN CHOLECYSTOKININ TYPE-B RECEPTOR GENE - ALTERNATIVE SPLICE DONOR SITE IN EXON-4 GENERATES 2 VARIANT MESSENGER-RNAS
Autore:
SONG I; BROWN DR; WILTSHIRE RN; GANTZ I; TRENT JM; YAMADA T;
Indirizzi:
UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,3101 TAUBMAN CTR ANN ARBOR MI48109 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,3101 TAUBMAN CTR ANN ARBOR MI48109 UNIV MICHIGAN,MED CTR,DEPT HUMAN GENET ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT SURG ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT RADIAT ONCOL ANN ARBOR MI 48109
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 90, anno: 1993,
pagine: 9085 - 9089
SICI:
0027-8424(1993)90:19<9085:THGCTR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; BRAIN; PANCREAS;
Keywords:
GASTROINTESTINAL HORMONE; G-PROTEIN-COUPLED RECEPTOR; GASTRIC FUNCTION; ALTERNATIVE SPLICE JUNCTION; CHROMOSOME-11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
I. Song et al., "THE HUMAN GASTRIN CHOLECYSTOKININ TYPE-B RECEPTOR GENE - ALTERNATIVE SPLICE DONOR SITE IN EXON-4 GENERATES 2 VARIANT MESSENGER-RNAS", Proceedings of the National Academy of Sciences of the United Statesof America, 90(19), 1993, pp. 9085-9089

Abstract

Gastrin and its carboxyl-terminal homolog cholecystokinin (CCK) exerta variety of biological actions in the brain and gastrointestinal tract that are mediated in part through one or more G protein-coupled receptors which exhibit similar affinity for both peptides. Genomic clones encoding a human gastrin/CCK(B) receptor were isolated by screening a human EMBL phage library with a partial-length DNA fragment which was based on the nucleotide sequence of the canine gastrin receptor. Thegene contained a 1356-bp open reading frame consisting of five exons interrupted by 4 introns and was assigned to human chromosome 11p15.4. A region of exon 4, which encodes a portion of the putative third intracellular loop, appears to be alternatively spliced to yield two different mRNAs, one containing (452 amino acids; long isoform) and the other lacking (447 amino acids; short isoform) the pentapeptide sequenceGly-Gly-Ala-Gly-Pro. The two receptor isoforms may contribute to functional differences in gastrin- and CCK-mediated signal transduction.

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Documento generato il 08/07/20 alle ore 01:19:18