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Titolo:
DUODENAL ACID-INDUCED INHIBITION OF GASTRIC-MOTILITY AND EMPTYING IN RATS
Autore:
RAYBOULD HE; HOLZER HH;
Indirizzi:
VET AFFAIRS MED CTR,CTR ULCER RES & EDUC,BLDG 115,RM 203,WILSHIRE & SAWTELLE BLVD LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,DEPT MED LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90073
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 265, anno: 1993,
parte:, 1
pagine: 70000540 - 70000546
SICI:
0002-9513(1993)265:3<70000540:DAIOGA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED FERRET; 5-HT3 RECEPTOR; VAGAL AFFERENT; CHOLECYSTOKININ; CAPSAICIN; SECRETION; TRANSPORT; SEROTONIN; VAGOTOMY; REFLEX;
Keywords:
GASTRIC EMPTYING; DUODENUM; SENSORY; CAPSAICIN; ACID; 5-HYDROXYTRYPTAMINE(3) RECEPTORS; SECRETIN; CHOLECYSTOKININ; URETHANE ANESTHESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Raybould e H.H. Holzer, "DUODENAL ACID-INDUCED INHIBITION OF GASTRIC-MOTILITY AND EMPTYING IN RATS", The American journal of physiology, 265(3), 1993, pp. 70000540-70000546

Abstract

The mechanism by which acid in the duodenum inhibits proximal gastricmotor function and delays emptying was investigated in urethan-anesthetized and awake rats. Gastric motility inhibited by duodenal acid (0.2 N HCI) in urethan-anesthetized rats was attenuated by 68 and 54%, respectively, by functional ablation of the vagal or spinal sensory innervation with capsaicin. 5-Hydroxytryptamine3 receptor blockade with zacopride (0.2 mg/kg ip) or cholecystokinin (CCK)-A-type receptor blockade with MK-329 (1 mg/kg ip) had no effect on the motility response to acid. In awake rats with chronically implanted gastric and duodenal cannulas, perfusion of the duodenum with acid (0.1 and 0.2 N HCI) inhibited gastric emptying of a nonnutrient liquid (38 and 59%, respectively). Blockade of CCK-A-type receptors reduced by 30% inhibition of gastric emptying induced by 0.1 N HCI. However, functional ablation of the vagal or spinal sensory innervation, 5-hydroxytryptamine3 receptor blockade, or immunoneutralization of secretin by systemic administration of a polyclonal antibody (no. 7842, 1 ml ip) had no effect on acid-induced (0.1 N HCl) inhibition of gastric emptying. Perfusion of the duodenum with 0.2 N HCI but not 0.1 N HCI inhibited proximal gastric motility in awake rats. These results suggest that 1) a duodenal acid load inhibits gastric emptying in part by a mechanism involving CCK and 2) decreased proximal gastric motility plays a minor role in inhibition of gastric emptying in response to acid.

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Documento generato il 01/10/20 alle ore 01:25:21