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Titolo:
SIGNAL-TRANSDUCTION VIA P2-PURINERGIC RECEPTORS FOR EXTRACELLULAR ATPAND OTHER NUCLEOTIDES
Autore:
DUBYAK GR; ELMOATASSIM C;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT PHYSIOL & BIOPHYS CLEVELAND OH 44106
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 265, anno: 1993,
parte:, 1
pagine: 30000577 - 30000606
SICI:
0002-9513(1993)265:3<30000577:SVPRFE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; AORTIC ENDOTHELIAL-CELLS; TRANSFORMED MOUSE FIBROBLASTS; PAROTID ACINAR-CELLS; BETA-GAMMA-SUBUNITS; PIG URINARY-BLADDER; RAT MAST-CELLS; EXOGENOUS ADENOSINE 5'-TRIPHOSPHATE; INTRACELLULAR CA-2+ CONCENTRATION;
Keywords:
G-PROTEINS; ION CHANNELS; PHOSPHOLIPASES; 2ND MESSENGERS; PROTEIN PHOSPHORYLATION; CELLULAR CALCIUM IONS; ECTOENZYMES; EXOCYTOSIS; SECRETION; PURINERGIC SIGNALING; ADENOSINE 5'-TRIPHOSPHATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
402
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Dubyak e C. Elmoatassim, "SIGNAL-TRANSDUCTION VIA P2-PURINERGIC RECEPTORS FOR EXTRACELLULAR ATPAND OTHER NUCLEOTIDES", The American journal of physiology, 265(3), 1993, pp. 30000577-30000606

Abstract

Extracellular ATP, at micromolar concentrations, induces significant functional changes in a wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or from exocytotic vesiclesand/or granules contained in many types of secretory cells. There arealso efficient extracellular mechanisms for the rapid metabolism of released nucleotides by ecto-ATPases and 5'-nucleotidases. The diverse biological responses to ATP are mediated by a variety of cell surface receptors that are activated when ATP or other nucleotides are bound. The functionally identified nucleotide or P2-purinergic receptors include 1) ATP receptors t at stimulate G protein-coupled effector enzymesand signaling cascades, including inositol phospholipid hydrolysis and the mobilization of intracellular Ca2+ stores; 2) ATP receptors thatdirectly activate ligand-gated cation channels in the plasma membranes of many excitable cell types; 3) ATP receptors that, via the rapid induction of surface membrane channels and/or pores permeable to ions and endogenous metabolites, produce cytotoxic or activation responses in macrophages and other immune effector cells; and 4) ADP receptors that trigger rapid ion fluxes and aggregation responses in platelets. Current research in this area is directed toward the identification and structural characterization of these receptors by biochemical and molecular biological approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:34:15