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Titolo:
CYTOKINE PRODUCTION DURING INTRAPERITONEAL CHEMOHYPERTHERMIA
Autore:
COULON L; GUTOWSKI MC; BARBIER M; GILLY FN; SAYAG A; BIENVENU J; BARBIER Y; PANTEIX G; CARRY PY; BRAILLON G;
Indirizzi:
CTR HOSP LYON SUD,DEPT IMMUNOL F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT IMMUNOL F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT RADIONAL F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT SURG F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT ANAESTHESIA & INTENS CARE F-69310 PIERRE BENITE FRANCE
Titolo Testata:
Oncology
fascicolo: 5, volume: 50, anno: 1993,
pagine: 371 - 374
SICI:
0030-2414(1993)50:5<371:CPDIC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MITOMYCIN-C; INTERLEUKIN-6; HYPERTHERMIA; CANCER; CELLS;
Keywords:
INTRAPERITONEAL CHEMOHYPERTHERMIA; CYTOKINE; INTERLEUKIN-6; TUMOR NECROSIS FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
L. Coulon et al., "CYTOKINE PRODUCTION DURING INTRAPERITONEAL CHEMOHYPERTHERMIA", Oncology, 50(5), 1993, pp. 371-374

Abstract

The aim of the present work is to investigate in vivo cytokine production during chemohyperthermia. 11 patients suffering from gastric adenocarcinoma (n = 6), ovarian adenocarcinoma (n = 4) or malignant mesothelioma (n = 1) were studied. Patients received 60 mg mitomycin or 100 mg cisplatin per square meter during 2 h in 6 liters of a heating solution (temperature 42-degrees-C, flow rate 200 ml/min in a closed circuit) after previous surgical resection. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were measured at 0, 30, 45, 60 and 90 min, both in the blood stream and in the heating solution circulating intraperitoneally. We observed a slight increase in plasma IL-6 occurring as soon as 30 min, a dramatic rise in IL-6 in the heating solution. TNF-alpha values were only slightly augmented. In addition, the importance of various factors in the induction of IL-6 and TNF-alpha production during chemohyperthermia (temperature, mitomycin C, cisplatin)were studied using a whole blood ex vivo model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:42:46