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Titolo:
STUDY OF THE PHARMACOKINETICS OF MITOMYCIN-C IN HUMANS DURING INTRAPERITONEAL CHEMOHYPERTHERMIA WITH SPECIAL MENTION OF THE CONCENTRATION IN LOCAL TISSUES
Autore:
PANTEIX G; CHERPIN L; GILLY FN; SAYAG A; BRACHET A; BALTASSAT P; GUILLAUMONT M; CUICHARD J; CARRY PY; SALLE B; BIENVENU J; BRAILLON G;
Indirizzi:
CTR HOSP LYON SUD,DEPT BIOCHIM BATIMENT 2A,SECTEUR JULES COURMONT F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT BIOCHEM F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT SURG F-69310 PIERRE BENITE FRANCE CTR HOSP LYON SUD,DEPT ANAESTHESIA & INTENS CARE F-69310 PIERRE BENITE FRANCE
Titolo Testata:
Oncology
fascicolo: 5, volume: 50, anno: 1993,
pagine: 366 - 370
SICI:
0030-2414(1993)50:5<366:SOTPOM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENETRATION; RELEVANCE;
Keywords:
CHEMOHYPERTHERMIA, INTRAPERITONEAL; MITOMYCIN-C; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G. Panteix et al., "STUDY OF THE PHARMACOKINETICS OF MITOMYCIN-C IN HUMANS DURING INTRAPERITONEAL CHEMOHYPERTHERMIA WITH SPECIAL MENTION OF THE CONCENTRATION IN LOCAL TISSUES", Oncology, 50(5), 1993, pp. 366-370

Abstract

The aim of this work is to estimate the 24-hour distribution and elimination of mitomycin C (MMC) during and after intraperitoneal chemohyperthermia (IPCH) in 18 patients (13 gastric adenocarcinoma, 3 pancreatic adenocarcinoma, 2 malignant mesothelioma) who received 60 mg MMC during 90-120 min 6 liters of heating solution HS; (42-degrees-C) or HS flowing at 0.4 liters/min a closed circuit. MMC assay in the serum, urine, HS and in local biopsies were performed by high performance liquid chromatography. The amount of MMC in HS decreased by 54.1 +/- 13.6% during IPCH. The maximum MMC levels in serum reached 0.4 +/- 0.18 mg/l45 min after the start of IPCH, then rapidly decreased. Only 1.77 +/-0.93 mg were recovered in urine in 24 h. These data are consistent with a large and rapid absorption, mostly in local tissue, demonstrated by the level in 7 post-IPCH biopsies (8.3 +/- 7.6 mg/kg).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:53:13