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Titolo:
ANALYSIS OF HLA-DQA1 AND HLA-DQB1 GENES IN MEXICAN-AMERICANS WITH INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
SANJEEVI CB; ZEIDLER A; SHAW S; ROTTER J; NEPOM GT; COSTIN G; RAFFEL L; EASTMAN S; KOCKUM I; WASSMUTH R; LERNMARK A;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT ENDOCRINOL,BOX 60500 S-10401 STOCKHOLM 60 SWEDEN USC,CHILDRENS HOSP,DIV DIABETES HYPERTENS & NUTR LOS ANGELES CA 00000 CEDARS SINAI MED CTR,DEPT MED & PEDIAT LOS ANGELES CA 90048 VIRGINIA MASON RES CTR SEATTLE WA 98101 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195
Titolo Testata:
Tissue antigens
fascicolo: 2, volume: 42, anno: 1993,
pagine: 72 - 77
SICI:
0001-2815(1993)42:2<72:AOHAHG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DQ-BETA-CHAIN; HLA-DQ; JAPANESE SUBJECTS; SUSCEPTIBILITY; ALLELE; ACID; ASSOCIATIONS; POSITION-57; HAPLOTYPES; CLONING;
Keywords:
TYPE-I (INSULIN-DEPENDENT) DIABETES; HLA-DQ; GENETIC SUSCEPTIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C.B. Sanjeevi et al., "ANALYSIS OF HLA-DQA1 AND HLA-DQB1 GENES IN MEXICAN-AMERICANS WITH INSULIN-DEPENDENT DIABETES-MELLITUS", Tissue antigens, 42(2), 1993, pp. 72-77

Abstract

Mexican American patients (n = 35) with insulin-dependent diabetes mellitus (IDDM) and control subjects (n = 39) were HLA-DQA and DQB typedby the polymerase chain reaction technique combined with allele-specific oligonucleotide probes. Either DQB10302 or DQB1*0201 was present among 91% (32/35) of the patients compared to 67% (26/39) of controls. Either DQA10501 or DQA1*0301 was present in all patients (100% or 35/35) compared to 29/39 (74%) (OR 12.06 Pc < 0.05) of controls. All four of these genes, in cis or trans, were present in 15/35 (43%) of the patients compared to 3/39 (8%) of controls (OR 9.0; Pc < 0.01). The presence of one or more non-susceptibility alleles showed a dose-relateddecrease in relative risk. Presence of aspartic acid (Asp) at position 57 of the DQ beta chain did not confer protection and non-Asp homozygozity did not confer susceptibility to IDDM in this ethnic group. In conclusion, susceptibility to IDDM in Mexican Americans is associated with particular DQA and DQB combinations, illustrates dose-dependent parameters and contradicts the critical residue hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:01:22