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Titolo:
DRUG-METABOLISM STUDIES USING INTRINSIC AND EXTRINSIC LABELS A DEMONSTRATION USING N-15 VS CL IN MIDAZOLAM
Autore:
SONG HC; ABRAMSON F;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,2300 EYE ST NW WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,2300 EYE ST NW WASHINGTON DC 20037
Titolo Testata:
Drug metabolism and disposition
fascicolo: 5, volume: 21, anno: 1993,
pagine: 868 - 873
SICI:
0090-9556(1993)21:5<868:DSUIAE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFACE MASS-SPECTROMETRY; SELECTIVE DETECTION; C-13;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Song e F. Abramson, "DRUG-METABOLISM STUDIES USING INTRINSIC AND EXTRINSIC LABELS A DEMONSTRATION USING N-15 VS CL IN MIDAZOLAM", Drug metabolism and disposition, 21(5), 1993, pp. 868-873

Abstract

The chemical reaction interface for mass spectrometry (CRIMS) has been used to evaluate the ability of an ''intrinsic'' label (chlorine) toreplace an ''extrinsic'' label (N-15) in a study of the metabolite profile of a drug, in this case the benzodiazepine anesthetic agent midazolam. We find equally high selectivity and comparable signal/noise characteristics for chlorine as for isotopic nitrogen demonstrating thatthe chlorine in midazolam is itself an effective label and that special synthesis to incorporate isotopic labels is not necessary. The power of either detection mode of CRIMS is shown by detecting 14 metabolites, whereas only four had been previously determined. The ratios of N-15/Cl for each metabolite peak along with conventional mass spectra provide clues to the structures of these new metabolites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:56:05