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Titolo:
SUDDEN INCREASE OF THE ST SEGMENT ELEVATION AT TIME OF REPERFUSION PREDICTS EXTENSIVE INFARCTS IN PATIENTS WITH INTRAVENOUS THROMBOLYSIS
Autore:
DISSMANN R; LINDERER T; GOERKE M; VONAMELN H; RENNHAK U; SCHRODER R;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM STEGLITZ,DEPT CARDIOPULM,HINDENBURGDAMM 30 W-1000 BERLIN 45 GERMANY
Titolo Testata:
The American heart journal
fascicolo: 4, volume: 126, anno: 1993,
pagine: 832 - 839
SICI:
0002-8703(1993)126:4<832:SIOTSS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY REPERFUSION; LEFT-VENTRICULAR FUNCTION; ENZYME-RELEASE; RAT-HEART; OCCLUSION; ISCHEMIA; THERAPY; STREPTOKINASE; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Dissmann et al., "SUDDEN INCREASE OF THE ST SEGMENT ELEVATION AT TIME OF REPERFUSION PREDICTS EXTENSIVE INFARCTS IN PATIENTS WITH INTRAVENOUS THROMBOLYSIS", The American heart journal, 126(4), 1993, pp. 832-839

Abstract

Within 4 hours from the onset of symptoms in 61 patients with myocardial infarction and intravenous thrombolysis, ST segment elevation and creatine phosphokinase (CK) were measured every 15 minutes. Because ofa premature enzyme rise, 42 patients (69%) were reperfused early (group 1). Immediately following reperfusion, eight of them (13%, group 1a) showed a marked increase of the ST elevation, in six of whom it was associated with clearly intensified chest pain. These patients exhibited a much steeper enzyme release and developed a larger enzymatic infarct size than patients (group lb) without an additional transient ST. elevation at reperfusion (CK peak 5.1 +/- 1.6 vs 9.8 +/- 4.2 hours after the start of thrombolysis; CK release 48 +/- 22 vs 19 +/- 18 IU/ml x hours, both p < 0.005). At angiography 11 days later, left ventricular function was significantly worse in group la than in group 1b (regional dyssynergic area 51 +/- 24 vs 21 +/- 18, global ejection fraction39 +/- 14 vs 58 +/- 11; both p < 0.0005). During intravenous thrombolysis in acute myocardial infarction, some patients show a marked transient increase of the ST segment elevation at reperfusion. Their enzymerise is very rapid and suggests a special reperfusion pattern. Most of these patients suffered large infarcts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:15:09