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Titolo:
NONINVASIVE DETECTION OF REPERFUSION AFTER THROMBOLYSIS BASED ON SERUM CREATINE-KINASE MB CHANGES AND CLINICAL-VARIABLES
Autore:
OHMAN EM; CHRISTENSON RH; CALIFF RM; GEORGE BS; SAMAHA JK; KEREIAKES DJ; WORLEY SJ; WALL TC; BERRIOS E; SIGMON KN; LEE K; TOPOL EJ;
Indirizzi:
DUKE UNIV,MED CTR,DEPT MED,DIV CARDIOL,BOX 3151 DURHAM NC 27710 CLEVELAND CLIN EDUC FDN,DEPT CARDIOL CLEVELAND OH 44106 RIVERSIDE METHODIST HOSP COLUMBUS OH 43214 MEM HOSP MEMPHIS TN 00000 CHRIST HOSP CINCINNATI OH 45219 LANCASTER GEN HOSP LANCASTER PA 00000
Titolo Testata:
The American heart journal
fascicolo: 4, volume: 126, anno: 1993,
pagine: 819 - 826
SICI:
0002-8703(1993)126:4<819:NDORAT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TRANSLUMINAL CORONARY ANGIOPLASTY; 12-MONTH FOLLOW-UP; PLASMINOGEN-ACTIVATOR; RANDOMIZED TRIAL; ARTERY PATENCY; THERAPY; STREPTOKINASE; ISOENZYME; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Ohman et al., "NONINVASIVE DETECTION OF REPERFUSION AFTER THROMBOLYSIS BASED ON SERUM CREATINE-KINASE MB CHANGES AND CLINICAL-VARIABLES", The American heart journal, 126(4), 1993, pp. 819-826

Abstract

Coronary artery patency after thrombolytic therapy has important prognostic implications for survival after acute myocardial infarction. The ability to noninvasively identify patients early after thrombolysis may therefore allow other strategies, such as adjunctive therapy or rescue angioplasty, to be used to restore patency of the infarct-relatedartery. This study examined the use of a rapid creatine kinase (CK)-MB assay in conjunction with selected clinical variables for noninvasive detection of reperfusion after thrombolysis. Patients were enrolled in a study evaluating accelerated plasminogen activator dose regimens with patency assessments by first angiographic injection during acute angiography at a median and interquartile range (25th and 75th percentiles) 142 (96,195) minutes after starting thrombolytic therapy. Serum CK-MB samples measured by a rapid dual monoclonal antibody assay were obtained in 207 patients before (baseline) and 30 minutes, 90 minutes,and 3 hours after starting thrombolytic therapy. In 109 patients a CK-MB sample was obtained within 10 minutes of acute angiography (angio sample). At acute angiography the infarct-related artery was patent (Thrombolysis In Myocardial Infarction trial grade 2 to 3 flow) in 71%. Baseline CK-MB values were similar in patients with and without later reperfusion at acute angiography: 3 (0,8) ng/ml and 0 (0,4) ng/ml, respectively. At acute angiography, patients with successful reperfusion had higher CK-MB values [46 (20,138) ng/ml] compared with patients with persistent occlusion of the infarct-related artery [8 (3,63) ng/ml;

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:12:48