Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ALPHA-1-ADRENOCEPTOR SUBTYPES MEDIATING THE NOREPINEPHRINE-INDUCED CONTRACTILE RESPONSE IN THE RAT VAS-DEFERENS
Autore:
QUEIROZNETO A; BALLEJO G;
Indirizzi:
UNIV SAO PAULO STATE,FAC AGRON & VET SCI,DEPT ANIM MORPHOL & PHYSIOL BR-14870-000 JABOTICABAL BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO BR-14100 RIBEIRAO PRE SP BRAZIL
Titolo Testata:
General pharmacology
fascicolo: 5, volume: 24, anno: 1993,
pagine: 1149 - 1153
SICI:
0306-3623(1993)24:5<1149:ASMTNC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE ANTAGONISTS; MOLECULAR-CLONING; SMOOTH-MUSCLE; RECEPTOR; CDNA; EXPRESSION; BINDING; CA-2+; SITES; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A. Queirozneto e G. Ballejo, "ALPHA-1-ADRENOCEPTOR SUBTYPES MEDIATING THE NOREPINEPHRINE-INDUCED CONTRACTILE RESPONSE IN THE RAT VAS-DEFERENS", General pharmacology, 24(5), 1993, pp. 1149-1153

Abstract

1. The effects of chlorethylclonidine (CEC), 5-methyl-urapidil (5-MU), ryanodine and prolonged exposition to norepinephrine (NE) on the concentration-response curves (CRC) to this agonist on the bisected rat vas deferens (RVD) were investigated. 2. CEC did not affect the 50% effective concentration (EC50) of NE in either the prostatic (PP) or the epididymal (EP) portions of the RVD. 3. 5-MU did not alter the EC50 ofNE in the PP but caused a significant and concentration-dependent rightward shift of the CRC to NE in the EP. 4. Ryanodine caused a shift to the right of the CRC to NE in the PP associated to a decrease in maximal response, but did not affect the CRC to NE in the EP. 5. Incubation of the EP with NE for 6 hr elicited a significant decrease in the maximal response with no changes in the EC50. Similar treatment of the PP was associated with a significant shift to the right of the CRC to NE without modifications in the maximal response. 6. These results suggest that in the RVD, NE interacts with two different alpha1-adrenoceptors subtypes which are disposed in a selective manner along the RVD: the alpha1a subtype in the EP, and a non-alpha1b-non-alpha1a adrenoceptor subtype mainly located at the PP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:14:09