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Titolo:
FUNCTIONAL EVIDENCE THAT THE CENTRAL RENIN-ANGIOTENSIN SYSTEM PLAYS AROLE IN THE PRESSOR - RESPONSE INDUCED BY CENTRAL INJECTION OF CARBACHOL
Autore:
SAAD WA; LUIZ AC; CAMARGO LAA; SILVEIRA JEN; FOGLIA S; MENANI JV; SAAD WA;
Indirizzi:
UNESP,DEPT CIENCIAS FISIOL,FAC ODONTOL,RUA HUMAITA 1680 BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 4, volume: 30, anno: 1997,
pagine: 493 - 496
SICI:
0100-879X(1997)30:4<493:FETTCR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL LAMINA TERMINALIS; CHOLINERGIC STIMULATION; NATRIURETIC RESPONSES; SEPTAL AREA; RATS; ACTIVATION; DRINKING; ANTAGONIST; INHIBITION; SUPPRESSES;
Keywords:
PRESSOR RESPONSE; CENTRAL ANGIOTENSIN; CARBACHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "FUNCTIONAL EVIDENCE THAT THE CENTRAL RENIN-ANGIOTENSIN SYSTEM PLAYS AROLE IN THE PRESSOR - RESPONSE INDUCED BY CENTRAL INJECTION OF CARBACHOL", Brazilian journal of medical and biological research, 30(4), 1997, pp. 493-496

Abstract

We investigated the effects of losartan, an AT(1)-receptor blocker, and ramipril, a converting enzyme inhibitor, on the presser response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptoragonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l mu l) into the LV blocked the presser response induced by ANG II(12 ng/l mu l) and carbachol (2 nmol/l mu l). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 +/- 1 and 28 +/- 2 mmHg, respectively, Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 +/- 1 and 5 +/- 2 mmHg, respectively), Theinjection of ramipril (12 ng/l mu l) prior to carbachol blocked the presser effect of carbachol to 7 +/- 3 mmHg, These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:12:07