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Titolo:
IMMUNE-SYSTEM OF THE SPONTANEOUSLY HYPERTENSIVE RAT .2. MORPHOLOGY AND FUNCTION
Autore:
PURCELL ES; WOOD GW; GATTONE VH;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT PATHOL & ONCOL KANSAS CITY KS 66103
Titolo Testata:
The Anatomical record
fascicolo: 2, volume: 237, anno: 1993,
pagine: 236 - 242
SICI:
0003-276X(1993)237:2<236:IOTSHR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL DEPRESSION; INTERLEUKIN-2 RECEPTORS; PROLACTIN; THYMUS; CORTICOSTERONE; AUTOANTIBODY; RESTORATION; SUPPRESSION; LYMPHOCYTES; INNERVATION;
Keywords:
THYMUS; SPLEEN; SPONTANEOUSLY HYPERTENSIVE RAT; INTERLEUKIN-2; T-LYMPHOCYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.S. Purcell et al., "IMMUNE-SYSTEM OF THE SPONTANEOUSLY HYPERTENSIVE RAT .2. MORPHOLOGY AND FUNCTION", The Anatomical record, 237(2), 1993, pp. 236-242

Abstract

The spontaneously hypertensive rat (SHR) is a stress-sensitive animalwhich exhibits moderate immune dysfunction that has been implicated in the onset of hypertension. In this study, we examined the morphologyof SHR thymus and spleen and further characterized the immune deficiency using Wistar-Kyoto (WKY) and Fisher 344 (F-344) rats for comparison. The adult SHR thymus does not display the increase in medullary volume typically noted with aging and the volume density of the marginal zone is decreased in the spleen. In vivo tritiated-thymidine incorporation is also decreased in the spleen of unstimulated SHR. In mixed lymphocyte reactions (MLR), the proliferative response of SHR splenocytesis significantly decreased relative to controls, WKY and F-344. Addition of interleukin-1 (IL-1), interleukin-2 (IL-2), or indomethacin to the MLR cultures does not increase proliferation. The proliferative response to T cell receptor monoclonal antibody (mAb-TCR) or interleukin-2 (IL-2) are similarly impaired in the SHR. The depressed proliferative T cell response is reversed by prolactin. It is suggested that the SHR is a valuable model for the study of immune deficiency. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:47:46