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Titolo:
ASCORBATE CONCENTRATION IN HUMAN CEREBROSPINAL-FLUID (CSF) AND SERUM - INTRATHECAL ACCUMULATION AND CSF FLOW-RATE
Autore:
REIBER H; RUFF M; UHR M;
Indirizzi:
UNIV GOTTINGEN,NEUROCHEM LAB,ROBERT KOCH STR 40 W-3400 GOTTINGEN GERMANY
Titolo Testata:
Clinica chimica acta
fascicolo: 2, volume: 217, anno: 1993,
pagine: 163 - 173
SICI:
0009-8981(1993)217:2<163:ACIHC(>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; ACID LEVELS; BARRIER;
Keywords:
VITAMIN-C; ASCORBATE; URIC ACID; CEREBROSPINAL FLUID (CSF); SERUM; CSF FLOW; BLOOD-CSF BARRIER FUNCTION; NEUROLOGICAL DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
H. Reiber et al., "ASCORBATE CONCENTRATION IN HUMAN CEREBROSPINAL-FLUID (CSF) AND SERUM - INTRATHECAL ACCUMULATION AND CSF FLOW-RATE", Clinica chimica acta, 217(2), 1993, pp. 163-173

Abstract

Concentrations of ascorbate (vitamin C) in cerebrospinal fluid (CSF) from human controls (median 163 mumol/l, n = 63) were found to be in the same range as CSF samples from patients (n = 56) with various neurological diseases, but excluding those with blood-CSF barrier dysfunction. The CSF/serum concentration ratio in the former group is non-linear, decreasing with increasing serum concentration. Surprisingly, ascorbate concentration in blood (median 41 mumol/l, n = 119) was decreasedsignificantly in cases of neurological diseases with a blood-CSF barrier dysfunction (median 26 mumol/l, n = 30). In this latter group a linear CSF to serum ratio with a mean of 5.7:1 (with CSF/serum albumin quotients QAlb = 7.8-70.8 . 10(-3), median 10.0 . 10(-3)) was observed,approaching a value > 12.5:1 in the case of complete stop of CSF flow. Serum ascorbate concentrations decreased with decreasing CSF flow rate (1 square-root QAlb), indicating a CSF flow-dependent constant contribution from high intrathecal ascorbate concentration to the varying diet-dependent concentrations in blood. In the control group the biological coefficient of variation for CSF ascorbate concentrations (C.V. = 2 1. 1%) was smaller than for serum concentrations (C.V. = 42.6%), confirming an efficient ascorbate homeostasis in human brain. This was different from uric acid which was used as a reference molecule with an inversed gradient in the same group of control patients. Similar variations in CSF(y) and serum(x) for urate concentrations are observed due to the strong correlation y = 0.1x +/- 10 mumol/l, including 99% ofthe cases with an urate serum concentration range from 80 mumol/l to 460 mumol/l.

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Documento generato il 25/01/20 alle ore 16:05:36