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Titolo:
IMPROVED FORMULAS FOR THE JUDGMENT OF INTRATHECALLY PRODUCED IGA AND IGM IN THE PRESENCE OF BLOOD CSF BARRIER DAMAGE
Autore:
OHMAN S; ERNERUDH J; FORSBERG P; VONSCHENCK H; VRETHEM M;
Indirizzi:
LINKOPING UNIV,DEPT CLIN CHEM S-58185 LINKOPING SWEDEN LINKOPING UNIV,DEPT NEUROL S-58185 LINKOPING SWEDEN LINKOPING UNIV,DEPT INFECT DIS S-58185 LINKOPING SWEDEN LINKOPING UNIV,DEPT TRANSFUS MED & CLIN IMMUNOL S-58185 LINKOPING SWEDEN
Titolo Testata:
Annals of clinical biochemistry
, volume: 30, anno: 1993,
parte:, 5
pagine: 454 - 462
SICI:
0004-5632(1993)30:<454:IFFTJO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS; NEUROLOGICAL DISEASES; REFERENCE VALUES; SIZE;
Keywords:
BLOOD CSF BARRIER; CEREBROSPINAL FLUID; REFERENCE INTERVAL; MULTIPLE SCLEROSIS; MENINGITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Ohman et al., "IMPROVED FORMULAS FOR THE JUDGMENT OF INTRATHECALLY PRODUCED IGA AND IGM IN THE PRESENCE OF BLOOD CSF BARRIER DAMAGE", Annals of clinical biochemistry, 30, 1993, pp. 454-462

Abstract

In order to discriminate between transsudated and intrathecally produced IgA and IgM in patients with blood cerebrospinal fluid (CSF) barrier (BCB) damage, we developed extended indices (IgA-EI and IgM-EI) forthese immunoglobulins according to the general formula for extended index of a component X in CSF: X-EI = (CSF-X/serum-X)/(CSF-albumin/serum-albumin)a where a is a parameter specific for X. For IgA parameter awas found to be 1.15 and for IgM 1.9. A preliminary evaluation of IgA-EI and IgM-EI indicated lower false positive rates as compared to CSFIgA and IgM concentrations as well as 'conventional' IgA and IgM indices in cases with BCB damage, and essentially the same rates as for the hyperbolic formulae of Reiber and Felgenhauer. The importance of reliable sampling and analytical technique for IgM in CSF is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:34:37