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Titolo:
RED-BLOOD-CELL AGGREGATION AND PRIMARY HYPERLIPOPROTEINEMIA
Autore:
VAYA A; MARTINEZ M; CARMENA R; AZNAR J;
Indirizzi:
HOSP LA FE,DEPT CLIN PATHOL VALENCIA SPAIN HOSP LA FE,DEPT CLIN PATHOL VALENCIA SPAIN HOSP CLIN VALENCIA,DEPT MED VALENCIA SPAIN
Titolo Testata:
Thrombosis research
fascicolo: 2, volume: 72, anno: 1993,
pagine: 119 - 126
SICI:
0049-3848(1993)72:2<119:RAAPH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN CHOLESTEROL; II HYPERLIPOPROTEINEMIA; ERYTHROCYTES; RHEOLOGY;
Keywords:
RED BLOOD CELL AGGREGATION; PRIMARY HYPERLIPOPROTEINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Vaya et al., "RED-BLOOD-CELL AGGREGATION AND PRIMARY HYPERLIPOPROTEINEMIA", Thrombosis research, 72(2), 1993, pp. 119-126

Abstract

Erythrocyte aggregation (EA) was determined in a Myrenne aggregometerat stasis (EAM(o)) and low shear (EAM1) in 102 patients suffering from primary hyperlipoproteinemia (PHLP)-46 with familial hypercholesterolemia (FH); 28 with familial combined hyperlipemia (FCHL); 28 with primary hypertriglyceridemia (PHTG)-and in a control group (CG) of healthy matched subjects. EA was also determined in FH after the autologous plasma had been replaced by a control plasma. The following parameterswere also measured: fibrinogen (Fbg), plasmatic lipids, apolipoproteins, glucose, HbA1 c and membrane erythrocyte lipids: cholesterol (C) and phospholipids (PL). An increase in both EAM(o) and EAM1 was observed in all the studied groups of patients. When erythrocytes of FH were resuspended in control plasma, EA normalized, but only in 75 % of them. Fbg was elevated only in FH and FCHL. Membrane C was increased mainly in FH and FCHL. EA correlates with both Fbg and apolipoproteins. In FH, EA also correlates with membrane C/PL. In addition, a high significant correlation exists between EA and HbA1 c in FCHL. The results obtained suggest that not only Fbg and apolipoproteins but also possible changes in erythrocyte membrane could encourage EA in PHLP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:30:47