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Titolo:
FAILURE TO FIND LINKAGE BETWEEN SCHIZOPHRENIA AND GENETIC-MARKERS ON CHROMOSOME-21
Autore:
ASHERSON P; MANT R; TAYLOR C; SARGEANT M; COLLIER D; CLEMENTS A; NANKO S; WHATLEY S; GILL M; MCGUFFIN P; OWEN M;
Indirizzi:
UNIV WALES COLL MED,DEPT PSYCHOL MED CARDIFF CF4 4XN S GLAM WALES INST PSYCHIAT,GENET SECT LONDON SE5 8AF ENGLAND INST PSYCHIAT,DEPT NEUROSCI LONDON SE5 8AF ENGLAND TEIKYO UNIV,SCH MED,DEPT PSYCHIAT TOKYO 173 JAPAN UNIV WALES COLL MED,DEPT MED GENET CARDIFF CF4 4XN S GLAM WALES
Titolo Testata:
American journal of medical genetics
fascicolo: 3, volume: 48, anno: 1993,
pagine: 161 - 165
SICI:
0148-7299(1993)48:3<161:FTFLBS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECURSOR PROTEIN GENE; DINUCLEOTIDE REPEAT; ALZHEIMERS-DISEASE; DNA POLYMORPHISMS; LOD SCORE; MUTATION; LOCUS; MAP;
Keywords:
MUTATIONS; AMYLOID PRECURSOR PROTEIN GENE; LINKAGE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Asherson et al., "FAILURE TO FIND LINKAGE BETWEEN SCHIZOPHRENIA AND GENETIC-MARKERS ON CHROMOSOME-21", American journal of medical genetics, 48(3), 1993, pp. 161-165

Abstract

We sought evidence for the involvement of mutations in the amyloid precursor protein gene (APP) in the pathogenesis of schizophrenia in twoways. First, linkage analysis was performed in a sample of 24 families multiply affected with schizophrenia. The genotypes were studied forGT12 (D21S210), a highly polymorphic microsatellite marker at the APPlocus. Second, we used single strand conformation analysis (SSCA) to screen for mutations in exon 17 of APP in one affected member from each family and in a sample of 44 unrelated patients. In addition, we looked for linkage between schizophrenia and a series of highly polymorphic markers situated at approximately 20cM intervals along the long armof chromosome 21. We were unable to find evidence for linkage to GT12or the other markers studied. SSCA did not reveal any mutations in exon 17 of APP. We conclude that mutations within APP are an unlikely cause of schizophrenia. Moreover, this study provides no evidence for a major gene for schizophrenia on chromosome 21, and linkage can be excluded from much of this region under some genetic models. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:04:59