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Titolo:
GAMMA-DELTA T-LYMPHOCYTES REGULATE THE INDUCTION AND MAINTENANCE OF ORAL TOLERANCE
Autore:
KE Y; PEARCE K; LAKE JP; ZIEGLER HK; KAPP JA;
Indirizzi:
EMORY UNIV,SCH MED,DEPT PATHOL,1327 CLIFTON RD NE,EMORY CLIN BLDG B,ROOM 4222 ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT PATHOL ATLANTA GA 30322 EMORY UNIV,SCH MED,WINSHIP CANC CTR ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT MICROBIOL IMMUNOL ATLANTA GA 30322
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 158, anno: 1997,
pagine: 3610 - 3618
SICI:
0022-1767(1997)158:8<3610:GTRTIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I PRESENTATION; EXOGENOUS ANTIGEN; INTRAEPITHELIAL LYMPHOCYTES; SOLUBLE-PROTEIN; IGE RESPONSES; MONOCLONAL-ANTIBODY; INVIVO ACTIVATION; EPITHELIAL-CELLS; MHC PRESENTATION; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ke et al., "GAMMA-DELTA T-LYMPHOCYTES REGULATE THE INDUCTION AND MAINTENANCE OF ORAL TOLERANCE", The Journal of immunology, 158(8), 1997, pp. 3610-3618

Abstract

Oral administration of Ag, over a period of several days, induces a state of tolerance that is associated with activation of CD8(+) T cellsthat can transfer unresponsiveness to naive syngeneic hosts. We previously demonstrated that these T cells are not CTL precursors and that they inhibit responses by CD8(+) CTL, as well as Ab and CD4(+) T cell responses. Activation of noncytolytic, CD8(+) suppressor T cells by oral Ag is a process that is not understood. In these studies, we asked whether depletion of the gamma delta T cells altered induction of oraltolerance. Injection of the anti-delta-chain Ab (GL3) down-modulated the expression of gamma delta TCR and inhibited the induction of oral tolerance to OVA, as measured by Ab, CD4(+), and CD8(+) T cell responses. GL3 did not activate IL-2 secretion that could be detected in the serum, nor did it induce IL-2R expression by intraepithelial lymphocytes, suggesting that GL3 inhibited the function of gamma delta T cells rather than activating them. This interpretation is supported by our observation that oral administration of Ag did not induce tolerance in TCR-delta knockout mice. These data suggest that gamma delta T cells play a critical, active role in tolerance induced by orally administered Ag.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:32:06