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Titolo:
ACUTE-LIVER-DISEASE ASSOCIATED WITH ERYTHROMYCINS, SULFONAMIDES, AND TETRACYCLINES
Autore:
CARSON JL; STROM BL; DUFF A; GUPTA A; SHAW M; LUNDIN FE; DAS K;
Indirizzi:
UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DIV GEN INTERNAL MED,97 PATERSON ST NEW BRUNSWICK NJ 08903 UNIV PENN,SCH MED,CTR CLIN EPIDEMIOL & BIOSTAT PHILADELPHIA PA 19104 HLTH INFORMAT DESIGNS INC ARLINGTON VA 00000 US FDA,DIV DRUG & BIOL PROD EXPERIENCE,EPIDEMIOL DEV BRANCH ROCKVILLEMD 20857
Titolo Testata:
Annals of internal medicine
fascicolo: 7, volume: 119, anno: 1993,
parte:, 1
pagine: 576 - 583
SICI:
0003-4819(1993)119:7<576:AAWESA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIMETHOPRIM-SULFAMETHOXAZOLE; INTRAHEPATIC CHOLESTASIS; HEPATIC CHOLESTASIS; SKIN RASH; HEPATOTOXICITY; SULFASALAZINE; MINOCYCLINE; ETHYLSUCCINATE; FAILURE;
Keywords:
HEPATITIS, TOXIC; ERYTHROMYCIN; SULFONAMIDES; TETRACYCLINES; HOSPITALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Carson et al., "ACUTE-LIVER-DISEASE ASSOCIATED WITH ERYTHROMYCINS, SULFONAMIDES, AND TETRACYCLINES", Annals of internal medicine, 119(7), 1993, pp. 576-583

Abstract

Objective: To determine whether erythromycins, sulfonamides, and tetracyclines are associated with an increased risk for acute hepatitis. Design: Case-control study. Setting: Medicaid billing data from Michigan and Florida between 1980 and 1987. Patients: The 107 cases included patients hospitalized with acute symptomatic hepatitis without an identifiable cause of liver disease noted in the medical record. Four controls per case were randomly selected and were matched for age, sex, and state. Results: Five cases (4.7%) and four controls (0.9%) were exposed to erythromycins, yielding an odds ratio of 5.2 (95% CI, 1.1 to 26.6). No case or control was exposed to erythromycin estolate. Eight cases (7.5%) and three controls (0.7%) were exposed to oral sultonamides, yielding an odds ratio of 11.4 (CI, 2.7 to 67.8). All (except one control) had received trimethoprimsulfamethoxazole. Five cases (4.7%) and four controls (0.9%) were exposed to tetracyclines, yielding an oddsratio of 5.2 (CI, 1.4 to 19.7). The results did not change substantively for erythromycin or sulfonamides after adjustment using multiple logistic regression for age, sex, state, and use of other hepatotoxic drugs. With tetracyclines, however, the odds ratio decreased to 3.6 (CI, 0.9 to 14.3). Associations were also seen with isoniazid (P = 0.008)and rifampicin (P = 0.04). The number of patients developing acute symptomatic liver disease resulting in hospitalization for each million patients treated with a 10-day course of erythromycin was 2.28 cases; for sulfonamides, this figure was 4.8 cases; and for tetracycline, thefigure was 1.56 cases. Conclusion: Erythromycin, sulfonamides, and tetracyclines are associated with acute symptomatic hepatitis resulting in hospitalization. Given the widespread use of these drugs, they willbe among the more common drugs associated with hepatitis.

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Documento generato il 20/02/20 alle ore 03:13:05