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Titolo:
IDENTIFICATION AND CHARACTERIZATION OF A SUBSTRATE-SPECIFIC FOR THE T-CELL PROTEIN-TYROSINE KINASE ZAP-70
Autore:
WATTS JD; BRABB T; BURES EJ; WANGE RL; SAMELSON LE; AEBERSOLD R;
Indirizzi:
UNIV WASHINGTON,DEPT MOL BIOTECHNOL,BOX 357730 SEATTLE WA 98195 NICHHD,NIH,CELL BIOL & METAB BRANCH BETHESDA MD 20892
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 398, anno: 1996,
pagine: 217 - 222
SICI:
0014-5793(1996)398:2-3<217:IACOAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; HUMAN ERYTHROCYTE BAND-3; IONIZATION MASS-SPECTROMETRY; TANDEM SH2 DOMAINS; ANTIGEN RECEPTOR; SIGNAL-TRANSDUCTION; ZETA-CHAIN; PHOSPHORYLATION; LYMPHOCYTE; ACTIVATION;
Keywords:
TYROSINE KINASE; T CELL; BAND 3 PROTEIN; ZAP-70; LCK; ITK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Watts et al., "IDENTIFICATION AND CHARACTERIZATION OF A SUBSTRATE-SPECIFIC FOR THE T-CELL PROTEIN-TYROSINE KINASE ZAP-70", FEBS letters, 398(2-3), 1996, pp. 217-222

Abstract

ZAP-70 is a protein tyrosine kinase (PTK) that plays a critical role in T cell activation, To study the role of ZAP-70 catalytic activity in this process, a substrate capable of distinguishing between the activities of ZAP-70 and other PTKs would be useful, especially since it has recently been shown that ZAP-70 interacts with another T cell PTK, Lck, We have thus identified a site of phosphorylation on the cytoplasmic fragment of the erythrocyte band 3 protein that is recognized by ZAP-70, but not Lck, A synthetic peptide based on this site has been demonstrated to be a good in vitro substrate for ZAP-70 and a poor substrate for the T cell PTKs Lck and Itk. This peptide molecule should thus prove useful to many investigators working in the field of T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:51:34