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Titolo:
THE MAP KINASE CASCADES ARE ACTIVATED DURING POSTISCHEMIC LIVER REPERFUSION
Autore:
BENDINELLI P; PICCOLETTI R; MARONI P; BERNELLIZAZZERA A;
Indirizzi:
UNIV MILAN,CNR,CTR STUDIO PATOL CELLULARE,IST PATOL GEN,VIA MANGIAGALLI 31 I-20133 MILAN ITALY UNIV MILAN,CNR,CTR STUDIO PATOL CELLULARE,IST PATOL GEN I-20133 MILANITALY
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 398, anno: 1996,
pagine: 193 - 197
SICI:
0014-5793(1996)398:2-3<193:TMKCAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION PATHWAY; HEAT-SHOCK PROTEINS; RAT-LIVER; TYROSINE KINASES; STRESS; PHOSPHORYLATION; RAF-1; INTERLEUKIN-1; SPECIFICITY; BINDING;
Keywords:
LIVER; POSTISCHEMIC REPERFUSION; MAPK CASCADE; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Bendinelli et al., "THE MAP KINASE CASCADES ARE ACTIVATED DURING POSTISCHEMIC LIVER REPERFUSION", FEBS letters, 398(2-3), 1996, pp. 193-197

Abstract

We have investigated the involvement of MAP kinase cascades in the response of the liver to post-ischemic reperfusion. Both JNKs and ERKs are activated but the duration and magnitude of the increase in their activities appear to be different, JNK activation is more marked but shorter than that of ERKs. The increase observed in the phosphotyrosine content of the 52 kDa She protein, accompanied by an increased amount of co-immunoprecipitated Grb2, and the activation of Raf-1 kinase provide evidence of the involvement of a Ras-Raf-dependent pathway, with atime course that is similar to that of ERK activation. The treatment of rats with IL-1 receptor antagonist modified all of the described effects, suggesting that IL-1 plays a role in the response of the liver to reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:28:11