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Titolo:
ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF THE TANNIN FRACTION FROM MYRACRODRUON URUNDEUVA FR ALL
Autore:
VIANA GSB; BANDEIRA MAM; MOURA LC; SOUZA MVP; MATOS FJA; RIBEIRO RA;
Indirizzi:
FED UNIV CEARA,DEPT PHYSIOL & PHARMACOL FORTALEZA CEARA BRAZIL FED UNIV CEARA,LAB NAT PROD FORTALEZA CEARA BRAZIL
Titolo Testata:
PTR. Phytotherapy research
fascicolo: 2, volume: 11, anno: 1997,
pagine: 118 - 122
SICI:
0951-418X(1997)11:2<118:AAAEOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEMORRHAGIC CYSTITIS; TUMOR-NECROSIS-FACTOR; NEUTROPHIL MIGRATION; FORMALIN; ALPHA;
Keywords:
ANTINOCICEPTIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; MIRACRODRUON URUNDEUVA; TANNIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G.S.B. Viana et al., "ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF THE TANNIN FRACTION FROM MYRACRODRUON URUNDEUVA FR ALL", PTR. Phytotherapy research, 11(2), 1997, pp. 118-122

Abstract

The present work showed a significant antinociceptive activity in thetannin fraction (TF) extracted from the bark of Myracrodruon urundeuva Fr. All. This inhibitory effect was demonstrated not only against abdominal contractions but also in the formalin test in mice. In the first case, at doses of 0.1 and 1 mg/kg, i.p. the TF caused inhibitions of the order of 39.6 % and 80.8 %, respectively, and in the second one,inhibitions of 47.8 % and 77.2 % (phase I) and 59.2% and 100% (phase II), after the administration of 5 and 10 mg/kg, i.p. The antinociceptive effect was partially reverted by naloxone. The TF presented also an antioedematogenic effect in rat paw oedema induced by carrageenan aswell as dextran. In the carrageenan model, significant inhibitions were seen at 2 h (29.7% and 41.7%) and 3 h (40.5% and 44.2%), after administration of 5 and 10 mg/kg, i.p. In the dextran induced oedema, the TF (10 mg/kg, p.o.) caused inhibitions of 29.2%, 42.4% and 54.5% at 2 h, 3 h and 4 h, respectively. The TF (10 and 25 mg/kg, i.p.) significantly inhibited the inflammatory events (vesical oedema and increased vascular permeability) which occur at the onset of the haemorrhagic cystitis induced by cyclophosphamide. After subcutaneous or oral administration, the TF (5-50 mg/kg) also blocked neutrophil migration induced by direct (fMLP) as well as indirect (carrageenan) stimuli. (C) 1997 by John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:12:38