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Titolo:
EXPOSURE TO ETHANOL UP-REGULATES THE EXPRESSION OF MYCOBACTERIUM-AVIUM COMPLEX PROTEINS ASSOCIATED WITH BACTERIAL VIRULENCE
Autore:
BERMUDEZ LE; YOUNG LS; MARTINELLI J; PETROFSKY M;
Indirizzi:
KUZELL INST,2200 WEBSTER ST,ROOM 305 SAN FRANCISCO CA 94115 CALIF PACIFIC MED CTR,MED RES INST SAN FRANCISCO,KUZELL INST ARTHRIT & INFECT DIS SAN FRANCISCO CA 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 168, anno: 1993,
pagine: 961 - 968
SICI:
0022-1899(1993)168:4<961:ETEUTE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEINS; SUPEROXIDE-DISMUTASE; HUMAN MACROPHAGES; GM-CSF; INFECTION; TUBERCULOSIS; ALCOHOLISM; DEFENSES; ANTIGENS; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "EXPOSURE TO ETHANOL UP-REGULATES THE EXPRESSION OF MYCOBACTERIUM-AVIUM COMPLEX PROTEINS ASSOCIATED WITH BACTERIAL VIRULENCE", The Journal of infectious diseases, 168(4), 1993, pp. 961-968

Abstract

Mycobacterium avium complex (MAC) organisms are the most common bacterial cause of disseminated infection in patients with AIDS. MAC, facultative intracellular bacteria, invade and multiply within macrophages. Treatment of MAC-infected macrophages with ethanol (10-100 mug/dL) isassociated with increased intracellular multiplication of MAC. To investigate whether this enhanced growth is due to a stress-related response induced by nonlethal concentrations of ethanol, strain 101 (serovar 1) was exposed to ethanol, and the regulation of the expression of proteins was examined. Exposure of MAC to ethanol (range, 10-100 mug/dL) was associated with up-regulation of the expression of a number of bacterial proteins, some of which (65 and 33 kDa) interfered with macrophage functions, such as production of superoxide anion and killing ofStaphylococcus aureus. Thus, exposure of MAC to small concentrations of ethanol may induce a stress-related response with consequent increase in the synthesis of proteins possibly associated with its ability to survive within macrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:31:55