Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HIGH-AFFINITY AMYLIN BINDING-SITES IN RAT-BRAIN
Autore:
BEAUMONT K; KENNEY MA; YOUNG AA; RINK TJ;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121
Titolo Testata:
Molecular pharmacology
fascicolo: 3, volume: 44, anno: 1993,
pagine: 493 - 497
SICI:
0026-895X(1993)44:3<493:HABIR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISLET AMYLOID POLYPEPTIDE; ACTIVATES GLYCOGEN-PHOSPHORYLASE; SKELETAL-MUSCLE; REGIONAL DISTRIBUTION; INSULIN RESISTANCE; DIABETES-MELLITUS; PANCREATIC AMYLIN; SOLEUS MUSCLE; CALCITONIN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Beaumont et al., "HIGH-AFFINITY AMYLIN BINDING-SITES IN RAT-BRAIN", Molecular pharmacology, 44(3), 1993, pp. 493-497

Abstract

Amylin, a 37-amino acid peptide structurally related to calcitonin gene-related peptide, is synthesized in and released along with insulin from pancreatic beta-cells. Amylin is proposed to act as an endocrine partner to insulin, in part through actions upon skeletal muscle that promote cycling of gluconeogenic precursors to liver. We report here that binding sites with high affinity (K(d) = 27 pm) for radioiodinatedrat amylin are present in the nucleus accumbens region of rat brain. Competition experiments show that sites measured in nucleus accumbens membranes have high affinity for rat amylin, lower affinity for rat calcitonin gene-related peptides, and very low affinity for rat calcitonin. In contrast to rat calcitonin, salmon calcitonin has a high affinity for these sites, indicating that it shares critical binding determinants with amylin. We further tested whether salmon calcitonin shares with amylin the ability to regulate glycogen metabolism in rat skeletal muscle. Salmon calcitonin potently inhibits insulin-stimulated glucose incorporation into rat soleus muscle glycogen, suggesting that rat skeletal muscle may also contain receptor populations that have high affinity for both amylin and salmon calcitonin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:26:18