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Titolo:
CHARACTERIZATION OF RECEPTORS FOR ENDOTHELINS IN THE PERFUSED ARTERIAL AND VENOUS MESENTERIC VASCULATURES OF THE RAT
Autore:
DORLEANSJUSTE P; CLAING A; WARNER TD; YANO M; TELEMAQUE S;
Indirizzi:
UNIV SHERBROOKE,SCH MED,DEPT PHARMACOL SHERBROOKE J1H 5N4 QUEBEC CANADA ST BARTHOLOMEWS HOSP,COLL MED,WILLIAM HARVEY RES INST LONDON EC1M 6BQENGLAND BANYU PHARMACEUT CO LTD,TSUKUBA RES INST TSUKUBA 30033 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 2, volume: 110, anno: 1993,
pagine: 687 - 692
SICI:
0007-1188(1993)110:2<687:CORFEI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETA-RECEPTOR; ANESTHETIZED RAT; VASOCONSTRICTOR; VASODILATOR; RESPONSES; RELEASE; BQ-123; POTENT; PROSTACYCLIN; CIRCULATION;
Keywords:
ENDOTHELIN-1; ENDOTHELIN-3; VASCULAR EFFECTS; ANTAGONIST; BQ-123; ENDOTHELIN RECEPTORS; MESENTERIC VASCULATURE; IRL 1620; BQ-3020;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P. Dorleansjuste et al., "CHARACTERIZATION OF RECEPTORS FOR ENDOTHELINS IN THE PERFUSED ARTERIAL AND VENOUS MESENTERIC VASCULATURES OF THE RAT", British Journal of Pharmacology, 110(2), 1993, pp. 687-692

Abstract

1 Endothelin-1 and -3 induced marked arterial and venous constrictions in the perfused mesenteric vasculature of the rat with endothelin-3 being at least 20 times less active than endothelin-1, on both arterial and venous sides of the vasculature. 2 Two ET(B) selective agonists,BQ-3020 and IRL 1620 (500 pmol), induced weak constrictions of the venous mesenteric vasculature and were inactive in the arterial side at doses up to 1000 pmol. 3 In mesenteric vasculatures precontracted witheither methoxamine (arterial side) or the thromboxane A2-mimetic, U46619 (venous side), acetylcholine or bradykinin produced vasodilatations of both arterial and venous vessels, whereas endothelin-3 induced vasodilatations only on the arterial side. 4 A selective ET(A) receptor antagonist, BQ-123, blocked, in a concentration-dependent and reversible fashion, the vasoconstrictions induced by endothelin-1 on both sides of the mesenteric circulation (IC50; arterial side: 0.013 muM; venous side: 0.032 muM). 5 In contrast, the vasodilator responses induced by endothelin-3 on the arterial side of the precontracted mesenteric vasculature were not affected by BQ-123. 6 The present study illustratesthe presence of ET(A) receptors which are responsible for vasoconstriction by endothelins in the arterial and venous mesenteric vasculatures. Furthermore, we suggest that the vasodilatations induced by endothelin-3 in the arterial vasculature uniquely, are ET(B) receptor-mediated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:14:50