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Titolo:
EFFECTS OF AGING ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) NEUROTOXIC EFFECTS ON STRIATUM AND BRAIN-STEM IN THE RAT
Autore:
DESOLE MS; ESPOSITO G; ENRICO P; MIELE M; FRESU L; DENATALE G; MIELE E; GRELLA G;
Indirizzi:
UNIV SASSARI,INST PHARMACOL,VIALE S PIETRO 43-B I-07100 SASSARI ITALY UNIV SASSARI,INST PHARMACEUT CHEM I-07100 SASSARI ITALY
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 159, anno: 1993,
pagine: 143 - 146
SICI:
0304-3940(1993)159:1-2<143:EOAO1(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE-BRAIN; 1-METHYL-4-PHENYLPYRIDINIUM;
Keywords:
MPTP NEUROTOXICITY; AGING; ANTIOXIDANT SYSTEM; STRIATUM; BRAIN-STEM; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Desole et al., "EFFECTS OF AGING ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) NEUROTOXIC EFFECTS ON STRIATUM AND BRAIN-STEM IN THE RAT", Neuroscience letters, 159(1-2), 1993, pp. 143-146

Abstract

In 3- and 18-month-old male Wistar rats, levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), noradrenaline (NA), uric acid, glutathione (GSH) and 1-methyl-4-phenylpyridinium ion (MPP+) were determined by HPLC in the striatum and/or in the brainstem 24 h after single injections of MPTP (12-35 mg/kg i.p.). Aged rats had lower baseline levels of AA and GSH, compared to young rats. In aged rats, MPTP 35 mg/kg induced a 70% death rate and a decrease in striatal DOPAC/DA ratio which was significantly correlated to MPP+ concentrations (r = -0.840, P < 0.005); in addition,MPTP did not increase AA oxidation. In the brainstem, the MPTP-induced decrease in NA levels and increase in uric acid levels were significantly correlated to the MPP+ concentrations (r = -0.709, P < 0.05, andr = +0.888, P < 0.001, respectively). In conclusion, evidence is given of a mechanism of toxicity of MPTP involving oxidative stress produced by xanthine oxidase; in addition, in aged rats the neuronal antioxidant system (levels of AA and GSH) is considerably lower than in youngrats and may play an enabling role in the MPTP age-related neurotoxiceffects on striatum and brainstem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:55:44