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Titolo:
TRANSMITTER-LIKE L-3,4-DIHYDROXYPHENYLALANINE TONICALLY FUNCTIONS TO MEDIATE VASODEPRESSOR CONTROL IN THE CAUDAL VENTROLATERAL MEDULLA OF RATS
Autore:
YUE JL; GOSHIMA Y; MISU Y;
Indirizzi:
YOKOHAMA CITY UNIV,SCH MED,DEPT PHARMACOL YOKOHAMA 236 JAPAN YOKOHAMA CITY UNIV,SCH MED,DEPT PHARMACOL YOKOHAMA 236 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 159, anno: 1993,
pagine: 103 - 106
SICI:
0304-3940(1993)159:1-2<103:TLTFTM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARII; L-DOPA; HYPOTHALAMIC SLICES; STRIATAL SLICES; ENDOGENOUS 3,4-DIHYDROXYPHENYLALANINE; BIPHASIC ACTIONS; EVOKED RELEASE; NORADRENALINE; MICRODIALYSIS; PROJECTIONS;
Keywords:
L-DOPA; D-DOPA; L-DOPA METHYL ESTER; DOPAMINE; NORADRENALINE; ALPHA-METHYL-P-TYROSINE; MICRODIALYSIS; ENDOGENOUS L-DOPA RELEASE; BLOOD PRESSURE; RAT CAUDAL VENTROLATERAL MEDULLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Yue et al., "TRANSMITTER-LIKE L-3,4-DIHYDROXYPHENYLALANINE TONICALLY FUNCTIONS TO MEDIATE VASODEPRESSOR CONTROL IN THE CAUDAL VENTROLATERAL MEDULLA OF RATS", Neuroscience letters, 159(1-2), 1993, pp. 103-106

Abstract

By microdialysis in the unilateral caudal ventrolateral medulla (CVLM) of anesthetized rats, the spontaneoUS L-3,4-dihydroxyphenylalanine (L-DOPA) release was in part tetrodotoxin-sensitive or Ca2+-dependent and was abolished by i.p. alpha-methyl-p-tyrosine (alpha-MPT), a tyrosine hydroxylase inhibitor. High K+ (50 mM) Ca2+-dependently evoked L-DOPA. By unilateral microinjections into the CVLM, L-DOPA (10-100 ng) produced dose-dependent, marked hypotension and bradycardia similarly inrats untreated, treated with i.p. 3-hydroxybenzylhydrazine, a centralDOPA decarboxylase inhibitor, or with i.v.t. 6-hydroxydopamine. Theseresponses were antagonized by L-DOPA methyl ester, a competitive L-DOPA antagonist. A depressor response to dopamine or noradrenaline (100 ng) was far smaller and slower in onset than that to L-DOPA (30 ng). D-DOPA (100 ng) produced no effect. Furthermore, L-DOPA methyl ester microinjected into bilateral CVLM produced some hypertension and tachycardia, which were markedly reduced by alpha-MPT. Transmitter-like L-DOPA tonically functions to mediate vasodepressor control in CVLM of rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:16:52