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Titolo:
PASSIVE BIOPHYSICAL MEMBRANE-PROPERTIES OF NUCLEUS-RETICULARIS GIGANTOCELLULARIS NEURONS IN BRAIN-SLICES FROM THE RAT
Autore:
YEN JC; CHAN SHH;
Indirizzi:
NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 159, anno: 1993,
pagine: 5 - 8
SICI:
0304-3940(1993)159:1-2<5:PBMONG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO; CAT; GUANABENZ; CHANNELS;
Keywords:
NUCLEUS RETICULARIS-GIGANTOCELLULARIS; BRAIN SLICE; TRANSMEMBRANE POTENTIAL; MEMBRANE INPUT RESISTANCE; MEMBRANE TIME CONSTANT; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Yen e S.H.H. Chan, "PASSIVE BIOPHYSICAL MEMBRANE-PROPERTIES OF NUCLEUS-RETICULARIS GIGANTOCELLULARIS NEURONS IN BRAIN-SLICES FROM THE RAT", Neuroscience letters, 159(1-2), 1993, pp. 5-8

Abstract

This study employed intracellular recording coupled with the current clamp technique to characterize the passive biophysical membrane properties of neurons in the nucleus reticularis gigantocellularis (NRGC) of brain slices from adult, male Sprague-Dawley rats. We found that NRGC neurons possessed highly depolarized transmembrane potentials (-22.9+/- 0.6 mV, n = 189). The 29 NRGC neurons that received further evaluation showed that they could be separated into two clusters, with significantly different membrane input resistances (3.51 +/- 0.89 vs 77.50+/- 8.82 MOMEGA) and membrane time constants (0.56 +/- 0.05 vs 1.27 +/- 0.12 ms). These membrane properties, which resembled qualitatively those we observed previously in cats in vivo, will form the basis for further evaluation of the ionic mechanisms that may underlie the actions of pharmacologic agents on the NRGC neurons.

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Documento generato il 28/09/20 alle ore 03:13:01